Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Perinatal maternal dietary supplementation of ω3-fatty acids transiently affects bone marrow microenvironment, osteoblast and osteoclast formation, and bone mass in male offspring
Other Titles: Perinatal maternal dietary supplementation of omega 3-fatty acids transiently affects bone marrow microenvironment, osteoblast and osteoclast formation, and bone mass in male offspring
Author: Fong, L.
Muhlhausler, B.
Gibson, R.
Xian, C.
Citation: Endocrinology, 2012; 153(5):2455-2465
Publisher: Endocrine Soc
Issue Date: 2012
ISSN: 0013-7227
Statement of
Laura Fong, Beverly S. Muhlhausler, Robert A. Gibson, and Cory J. Xian
Abstract: It is increasingly evident that micronutrient environment experienced before birth and in infancy is important for achieving optimal bone mass by adolescence and maintaining bone health. This study determined whether maternal supplementation with ω3-polyunsaturated fatty acids (n3FA) improved offspring bone growth and adult bone mass. Female rats were fed a diet containing 0.1% (control, n = 10) or 1% (n3FA, n = 11) docosahexanoic acid (DHA) during pregnancy and lactation. Offspring were weaned onto a control rat chow diet. Tibial growth plate and metaphysis structure, osteoblast/osteoclast density and differentiation, and gene expression were assessed in offspring at 3 wk (weaning), 6 wk (adolescent), and 3 months (adult). Maternal n3FA supplementation elevated offspring plasma n3FA levels at 3 and 6 wk. Although total growth plate heights were unaffected at any age, the resting zone thickness was increased in both male and female offspring at 3 wk. In n3FA males, but not females, bone trabecular number and thickness were increased at 3 wk but not other ages. The wk 3 n3FA males also exhibited an increased bone volume, an increased osteoblast but decreased osteoclast density, and lower expression of osteoclastogenic cytokines receptor activator of nuclear factor-κB ligand, TNF-α, and IL-6. No effects were seen at 6 wk or 3 months in either sex. Thus, perinatal n3FA supplementation is associated with increased bone formation, decreased resorption, and a higher bone mass in males, but not in females, at weaning; these effects do not persist into adolescence and adulthood and are unlikely to produce lasting improvements in bone health.
Keywords: Bone and Bones; Osteoclasts; Osteoblasts; Bone Marrow; Animals; Rats; Rats, Wistar; Prenatal Exposure Delayed Effects; Fatty Acids, Omega-3; Pregnancy; Bone Density; Dietary Supplements; Female; Male; Maternal Nutritional Physiological Phenomena
Rights: Copyright © 2012 by The Endocrine Society
RMID: 0020119135
DOI: 10.1210/en.2011-1917
Appears in Collections:Physiology publications

Files in This Item:
File Description SizeFormat 
hdl_73057.pdfSubmitted version482.77 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.