Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73239
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?
Author: Hickey, T.
Robinson, J.
Carroll, J.
Tilley, W.
Citation: Molecular Endocrinology, 2012; 26(8):1252-1267
Publisher: Endocrine Soc
Issue Date: 2012
ISSN: 0888-8809
1944-9917
Statement of
Responsibility: 
T. E. Hickey, J. L. L. Robinson, J. S. Carroll, and W. D. Tilley
Abstract: Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breast cancers. Conversely, AR signaling may promote growth of a subset of ERα-negative, AR-positive breast cancers with a molecular apocrine phenotype. Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.
Keywords: Mammary Glands, Human; Animals; Humans; Breast Neoplasms; Growth Inhibitors; Receptors, Androgen; Estrogen Receptor alpha; Androgens; Signal Transduction; Genes, Tumor Suppressor; Oncogenes; Female
Rights: Copyright © 2012 by The Endocrine Society
RMID: 0020121259
DOI: 10.1210/me.2012-1107
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.