Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73239
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dc.contributor.authorHickey, T.en
dc.contributor.authorRobinson, J.en
dc.contributor.authorCarroll, J.en
dc.contributor.authorTilley, W.en
dc.date.issued2012en
dc.identifier.citationMolecular Endocrinology, 2012; 26(8):1252-1267en
dc.identifier.issn0888-8809en
dc.identifier.issn1944-9917en
dc.identifier.urihttp://hdl.handle.net/2440/73239-
dc.description.abstractAndrogen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breast cancers. Conversely, AR signaling may promote growth of a subset of ERα-negative, AR-positive breast cancers with a molecular apocrine phenotype. Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.en
dc.description.statementofresponsibilityT. E. Hickey, J. L. L. Robinson, J. S. Carroll, and W. D. Tilleyen
dc.language.isoenen
dc.publisherEndocrine Socen
dc.rightsCopyright © 2012 by The Endocrine Societyen
dc.subjectMammary Glands, Human; Animals; Humans; Breast Neoplasms; Growth Inhibitors; Receptors, Androgen; Estrogen Receptor alpha; Androgens; Signal Transduction; Genes, Tumor Suppressor; Oncogenes; Femaleen
dc.titleMinireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?en
dc.typeJournal articleen
dc.identifier.rmid0020121259en
dc.identifier.doi10.1210/me.2012-1107en
dc.identifier.pubid23556-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHickey, T. [0000-0002-2752-730X]en
dc.identifier.orcidTilley, W. [0000-0003-1893-2626]en
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