Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73241
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Type: Journal article
Title: Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain
Author: Baune, B.
Konrad, C.
Grotegerd, D.
Suslow, T.
Birosova, E.
Ohrmann, P.
Bauer, J.
Arolt, V.
Heindel, W.
Domschke, K.
Schoning, S.
Rauch, A.
Uhlmann, C.
Kugel, H.
Dannlowski, U.
Citation: Journal of Neuroinflammation, 2012; 9(1):1-9
Publisher: BioMed Central Ltd.
Issue Date: 2012
ISSN: 1742-2094
1742-2094
Statement of
Responsibility: 
Bernhard T Baune, Carsten Konrad, Dominik Grotegerd, Thomas Suslow, Eva Birosova, Patricia Ohrmann, Jochen Bauer, Volker Arolt, Walter Heindel, Katharina Domschke, Sonja Schöning, Astrid V Rauch, Christina Uhlmann, Harald Kugel and Udo Dannlowski
Abstract: Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes. In this study the potential dual role of several IL-6 polymorphisms in brain morphology is investigated. Methodology: In a large sample of healthy individuals (N = 303), associations between genetic variants of IL-6 (rs1800795; rs1800796, rs2069833, rs2069840) and brain volume (gray matter volume) were analyzed using voxel-based morphometry (VBM). Selection of single nucleotide polymorphisms (SNPs) followed a tagging SNP approach (e.g., Stampa algorigthm), yielding a capture 97.08% of the variation in the IL-6 gene using four tagging SNPs. Principal findings/results: In a whole-brain analysis, the polymorphism rs1800795 (−174 C/G) showed a strong main effect of genotype (43 CC vs. 150 CG vs. 100 GG; x = 24, y = −10, z = −15; F(2,286) = 8.54, puncorrected = 0.0002; pAlphaSim-corrected = 0.002; cluster size k = 577) within the right hippocampus head. Homozygous carriers of the G-allele had significantly larger hippocampus gray matter volumes compared to heterozygous subjects. None of the other investigated SNPs showed a significant association with grey matter volume in whole-brain analyses. Conclusions/significance: These findings suggest a possible neuroprotective role of the G-allele of the SNP rs1800795 on hippocampal volumes. Studies on the role of this SNP in psychiatric populations and especially in those with an affected hippocampus (e.g., by maltreatment, stress) are warranted.
Keywords: Genetics; Inflammation; Interleukin 6; Neuroprotection; Voxel-based morphometry
Rights: © 2012 Baune et al.; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0020120994
DOI: 10.1186/1742-2094-9-125
Published version: http://www.jneuroinflammation.com/content/9/1/125
Appears in Collections:Psychiatry publications

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