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https://hdl.handle.net/2440/73526
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Type: | Journal article |
Title: | Polymer micelles for delayed release of therapeutics from drug-releasing surfaces with nanotubular structures |
Author: | Aw, M. Addai-Mensah, J. Losic, D. |
Citation: | Macromolecular Bioscience, 2012; 12(8):1048-1052 |
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
Issue Date: | 2012 |
ISSN: | 1616-5187 1616-5195 |
Statement of Responsibility: | Moom Sinn Aw, Jonas Addai-Mensah, Dusan Losic |
Abstract: | A new approach to engineer a local drug delivery system with delayed release using nanostructured surface with nanotube arrays is presented. TNT arrays electrochemically generated on a titanium surface are used as a model substrate. Polymer micelles as drug carriers encapsulated with drug are loaded at the bottom of the TNT structure and their delayed release is obtained by loading blank micelles (without drug) on the top. The delayed and time-controlled drug release is successfully demonstrated by controlling the ratio of blank and drug loaded-micelles. The concept is verified using four different polymer micelles (regular and inverted) loaded with water-insoluble (indomethacin) and water-soluble drugs (gentamicin). |
Keywords: | delayed drug release drug-carriers gentamicin indomethacin titania nanotubes |
Rights: | Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
DOI: | 10.1002/mabi.201200012 |
Grant ID: | http://purl.org/au-research/grants/arc/DP0770930 http://purl.org/au-research/grants/arc/LP0989229 |
Published version: | http://dx.doi.org/10.1002/mabi.201200012 |
Appears in Collections: | Aurora harvest 5 Chemical Engineering publications |
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