Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes|
|Citation:||Immunity, 1997; 7(2):283-290|
|Linde Meyaard, Gosse J Adema, Chiwen Chang, Erica Woollatt, Grant R Sutherland, Lewis L Lanier, Joseph H Phillips|
|Abstract:||In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.|
|Keywords:||Leukocytes, Mononuclear; Killer Cells, Natural; HL-60 Cells; Jurkat Cells; Tumor Cells, Cultured; Humans; Intracellular Signaling Peptides and Proteins; Receptors, Immunologic; DNA, Complementary; RNA, Messenger; Cloning, Molecular; Amino Acid Sequence; Base Sequence; Protein Binding; Molecular Sequence Data; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatase, Non-Receptor Type 11|
|Appears in Collections:||Paediatrics publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.