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Type: Journal article
Title: LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
Author: Meyaard, L.
Adema, G.
Chang, C.
Woollatt, E.
Sutherland, G.
Lanier, L.
Phillips, J.
Citation: Immunity, 1997; 7(2):283-290
Publisher: CELL PRESS
Issue Date: 1997
ISSN: 1074-7613
Statement of
Linde Meyaard, Gosse J Adema, Chiwen Chang, Erica Woollatt, Grant R Sutherland, Lewis L Lanier, Joseph H Phillips
Abstract: In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.
Keywords: Leukocytes, Mononuclear; Killer Cells, Natural; HL-60 Cells; Jurkat Cells; Tumor Cells, Cultured; Humans; Intracellular Signaling Peptides and Proteins; Receptors, Immunologic; DNA, Complementary; RNA, Messenger; Cloning, Molecular; Amino Acid Sequence; Base Sequence; Protein Binding; Molecular Sequence Data; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatase, Non-Receptor Type 11
RMID: 0030005592
DOI: 10.1016/S1074-7613(00)80530-0
Appears in Collections:Paediatrics publications

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