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https://hdl.handle.net/2440/74431
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Type: | Journal article |
Title: | Inflammatory biomarkers predict depressive, but not anxiety symptoms during aging: the prospective Sydney Memory and Aging Study |
Author: | Baune, B. Smith, E. Reppdermund, S. Air, T. Samaras, K. Lux, O. Brodaty, H. Sachdev, P. Trollor, J. |
Citation: | Psychoneuroendocrinology, 2012; 37(9):1521-1530 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2012 |
ISSN: | 0306-4530 1873-3360 |
Statement of Responsibility: | B.T. Baune, E. Smith, S. Reppermund, T. Air, K. Samaras, O. Lux, H. Brodaty, P. Sachdev and J.N. Trollor |
Abstract: | This study addresses the paucity of research on the prospective relationship between a range of inflammatory markers and symptoms of depression and anxiety during aging. In the Sydney Memory and Aging Study, the relationships between remitted depression, current and first onset of symptoms of depression or anxiety (Geriatric Depression Scale and Goldberg Anxiety Scale (GDS, GAS), and markers of systemic inflammation (C-reactive protein (CRP), interleukins-1β, -6, -8, -10, -12, plasminogen activator inhibitor-1 (PAI-1), serum amyloid A, tumor necrosis factor-α, and vascular adhesion molecule-1) were investigated. The sample consists of N=1037 non-demented community-dwelling elderly participants aged 70-90 years assessed at baseline and after 2-years. All analyses were adjusted for gender, age, years of education, total number of medical disorders diagnosed by a doctor, cardiovascular disorders, endocrine disorders, smoking, body mass index, currently using anti-depressants, NSAIDS or statins and diabetes mellitus. The results show a significant linear relationship between increasing levels of IL-6 and depressive symptoms at baseline only, whereas IL-8 was associated with depressed symptoms at baseline and at 2 years follow-up. In addition, IL-8 was associated with first onset of mild to moderate depressive symptoms over 2 years. Logistic regression analyses showed that PAI-1 (OR=1.37, 95% CI=1.10-1.71, p=0.005) was associated with remitted depression. Results for anxiety symptoms were negative. The findings are suggestive of IL-6 and IL-8 being associated with current symptoms and IL-8 being associated with first onset of depressive symptoms, whereas PAI-1 could be regarded as a marker of remitted depression. |
Keywords: | Humans Inflammation Tumor Necrosis Factor-alpha C-Reactive Protein Plasminogen Activator Inhibitor 1 Vascular Cell Adhesion Molecule-1 Interleukins Risk Factors Follow-Up Studies Predictive Value of Tests Depression Anxiety Memory Psychiatric Status Rating Scales Neuropsychological Tests Aging Aged Aged, 80 and over Female Male Biomarkers |
Rights: | © 2012 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.psyneuen.2012.02.006 |
Published version: | http://dx.doi.org/10.1016/j.psyneuen.2012.02.006 |
Appears in Collections: | Aurora harvest 4 Psychiatry publications |
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