Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/74530
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Cushing's mechanism maintains cerebral perfusion pressure in experimental subarachnoid haemorrhage |
Author: | Barry, C. Van Den Heuvel, C. Helps, S. Vink, R. |
Citation: | Neuroscience Letters, 2012; 529(1):92-96 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2012 |
ISSN: | 0304-3940 1872-7972 |
Statement of Responsibility: | Christine M. Barry, Corinna van den Heuvel, Stephen Helps, Robert Vink |
Abstract: | Mortality following subarachnoid haemorrhage (SAH) is high, especially within the first 48 h. Poor outcome is predicted by high intracranial pressure which causes diminished cerebral perfusion pressure unless a compensatory increase in mean arterial blood pressure occurs. Therefore blood pressure elevation can be protective following subarachnoid haemorrhage despite the potential for rebleeding. This study investigated blood pressure responses to SAH and the impact on cerebral perfusion pressure and outcome, as demonstrated by two experimental models. Various blood pressure responses were demonstrated, both at the ictus and within the following 5h. Elevated MABP at the ictus and at 2h following experimental SAH was associated with maintenance of CPP in the presence of raised ICP. Poor outcome (arrest of the cerebral circulation) was predicted by failure of MABP to increase significantly above sham levels within 2h of SAH. Rat SAH provides relatively inexpensive models to investigate physiological mechanisms that maintain cerebral perfusion in the presence of intracranial hypertension. |
Keywords: | Subarachnoid haemorrhage Intracranial hypertension Intracranial pressure Cerebral perfusion pressure Cushing response Blood pressure |
Rights: | © 2012 Elsevier Ireland Ltd. All rights reserved. |
DOI: | 10.1016/j.neulet.2012.08.057 |
Published version: | http://dx.doi.org/10.1016/j.neulet.2012.08.057 |
Appears in Collections: | Aurora harvest 4 Pathology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.