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|Title:||Comparative Genomic Hybridization|
|Author:||Hussey, Nicole Dominique|
Hu, Dong Gui
|Assignee:||Adelaide Research & Innovation Pty Ltd|
|School/Discipline:||School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology|
|Contributor:||Phillips Ormonde Fitzpatrick|
|Invented by N. D. Hussey, D. G. Hu; Assigned to Adelaide Research & Innovation Pty Ltd; Phillips Ormonde Fitzpatrick agents for inventors.|
|Abstract:||The present invention relates to a method of comparing at least one chromosome or part thereof from a cell with a first karyotype with the corresponding chromosome or part thereof from a cell with a second karyotype. The method includes the steps of: (a) amplifying DNA from an isolated chromosome or part of an isolated chromosome; (b) attaching the amplified DNA to a solid substrate; (c) amplifying DNA from one or more cells with a first karyotype and amplifying DNA from one or more cells with a second karyotype; (d) labelling the amplified DNA from the one or more cells with a first karyotype with a first label, and labelling the amplified DNA from the one or more cells with a second karyotype with a second label, wherein the first and second labels are detectably different; (e) hybridizing the amplified and labelled DNA from the one or more cells with a first karyotype to the amplified DNA attached to the solid substrate, and hybridizing the amplified and labelled DNA from the one or more cells with a second karyotype to the amplified DNA attached to the solid substrate; and (f) comparing the relative amount of first and second labels hybridized to the amplified DNA attached to the solid substrate.|
|Keywords:||AU 2004/225908 B2|
|Description:||PATENT: N. D. Hussey, D. G. Hu (Assignee: Adelaide Research & Innovation Pty Ltd). AU 2004/225908 B2 (WO 2004/088310 A1) filed Apr 2, 2004; published (WIPO) Oct 14, 2004; accepted journal date May 28, 2009.|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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