Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7493
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Type: Journal article
Title: C160rf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain
Author: Bhalla, K.
Eyre, H.
Whitmore, S.
Sutherland, G.
Callen, D.
Citation: Journal of Human Genetics, 1999; 44(6):383-387
Publisher: SPRINGER-VERLAG TOKYO
Issue Date: 1999
ISSN: 1434-5161
1435-232X
Statement of
Responsibility: 
Kavita Bhalla, Helen J. Eyre, Scott A. Whitmore, Grant R. Sutherland and David F. Callen
Abstract: A novel gene has been characterized, designated C16orf5, with an unusually high content of proline residues (40% over 104 residues) at the N-terminus of the protein. The C-terminus of the protein is also cysteine rich with 14 cysteine residues present. Analysis using Northern and dot blots showed that the highest expression of this gene is in the brain. The gene was located on chromosome 16 at band p13.3 by FISH to metaphase chromosomes. Southern blot analysis with a human–rodent somatic cell hybrid panel showed a location between the somatic hybrid breakpoints 23HA and CY196. This gene comprises at least four exons and an open reading frame of 786 bp encoding a predicted protein of 261 amino acids. Analysis of this protein using PSORTII predicted a nuclear localization.
Keywords: Proline; Cysteine; Brain; Chromosome 16p13.3
Description: The original publication can be found at www.springerlink.com
RMID: 0030005533
DOI: 10.1007/s100380050183
Appears in Collections:Paediatrics publications

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