Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/74996
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Full metadata record
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dc.contributor.author | Hasan, M. | - |
dc.contributor.author | Abbott, D. | - |
dc.contributor.author | Baumert, M. | - |
dc.contributor.editor | Frangogiannis, N. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | PLoS One, 2012; 7(11):1-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2440/74996 | - |
dc.description.abstract | OBJECTIVES: Increased beat-to-beat variability in the QT interval has been associated with heart disease and mortality. The purpose of this study was to investigate the beat-to-beat spatial and temporal variations of ventricular depolarization and repolarization in vectorcardiogram (VCG) for characterising myocardial infarction (MI) patients. METHODS: Standard 12-lead ECGs of 84 MI patients (22 f, 63±12 yrs; 62 m, 56±10 yrs) and 69 healthy subjects (17 f, 42±18 yrs; 52 m, 40±13 yrs) were investigated. To extract the beat-to-beat QT intervals, a template-matching algorithm and the singular value decomposition method have been applied to synthesise the ECG data to VCG. Spatial and temporal variations in the QRS complex and T-wave loops were studied by investigating several descriptors (point-to-point distance variability, mean loop length, T-wave morphology dispersion, percentage of loop area, total cosine R-to-T). RESULTS: Point-to-point distance variability of QRS and T-loops (0.13±.04 vs. 0.10±0.04, p<0.0001 and 0.16±.07 vs. 0.13±.06, p<0.05) were significantly larger in the MI group than in the control group. The average T-wave morphology dispersion was significantly higher in the MI group than in the control group (62±8 vs. 38±16, p<.0001). Further, its beat-to-beat variability appeared significantly lower in the MI group than in the control group (12±5 v. 15±6u, p<0.005). Moreover, the average percentage of the T-loop area was found significantly lower in the MI group than the controls (46±17 vs. 55±15, p<.001). Finally, the average and beat-to-beat variability of total cosine R-to-T were not found statistically significant between both groups. CONCLUSIONS: Beat-to-beat assessment of VCG parameters may have diagnostic attributes that might help in identifying MI patients. | - |
dc.description.statementofresponsibility | Muhammad A. Hasan, Derek Abbott and Mathias Baumert | - |
dc.language.iso | en | - |
dc.publisher | Public Library of Science | - |
dc.rights | © 2012 Hasan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.source.uri | http://dx.doi.org/10.1371/journal.pone.0049489 | - |
dc.subject | Humans | - |
dc.subject | Heart Ventricles | - |
dc.subject | Myocardial Infarction | - |
dc.subject | Vectorcardiography | - |
dc.subject | Case-Control Studies | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Electrocardiography | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Beat-to-beat vectorcardiographic analysis of ventricular depolarization and repolarization in myocardial infarction | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1371/journal.pone.0049489 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Abbott, D. [0000-0002-0945-2674] | - |
dc.identifier.orcid | Baumert, M. [0000-0003-2984-2167] | - |
Appears in Collections: | Aurora harvest 7 Electrical and Electronic Engineering publications |
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hdl_74996.pdf | Published version | 719.76 kB | Adobe PDF | View/Open |
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