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Type: Journal article
Title: Chemotherapy-induced gut toxicity: are alterations to intestinal tight junctions pivotal?
Author: Wardill, H.
Bowen, J.
Gibson, R.
Citation: Cancer Chemotherapy and Pharmacology, 2012; 70(5):627-635
Publisher: Springer
Issue Date: 2012
ISSN: 0344-5704
Statement of
Hannah R. Wardill, Joanne M. Bowen and Rachel J. Gibson
Abstract: Chemotherapy-induced gut toxicity (CIGT) is a frequent, debilitating and dose-limiting side effect of anticancer cytotoxic therapies. Despite much research, many of the underlying mechanisms remain poorly understood. Recently, there has been renewed interest in the role that intestinal permeability and tight junctions play in the pathogenesis of chemotherapy-induced gut toxicity. Tight junctions have been linked with many of the known hall marks of toxicity including pro-inflammatory cytokines and pathogenic bacteria. In this critical review, we highlight the research literature addressing modifications in tight junctions following chemotherapy administration and how tight junctions may be implicated in the pathophysiology of CIGT.
Keywords: Tight junctions; mucositis; occludin; pro-inflammatory cytokines; intestinal microflora; chemotherapy
Rights: © Springer-Verlag Berlin Heidelberg 2012
RMID: 0020123058
DOI: 10.1007/s00280-012-1989-5
Appears in Collections:Medical Sciences publications

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