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Type: Journal article
Title: Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka
Author: Andraweera, P.
Dekker, G.
Dissanayake, V.
Bianco-Miotto, T.
Jayasekara, R.
Roberts, C.
Citation: The Journal of Maternal - Fetal & Neonatal Medicine, 2013; 26(5):532-536
Publisher: Taylor & Francis Ltd
Issue Date: 2013
ISSN: 1476-7058
Statement of
Prabha H. Andraweera, Gustaaf A. Dekker, Vajira H.W. Dissanayake, Tina Bianco-Miotto, Rohan W. Jayasekara and Claire T. Roberts
Abstract: OBJECTIVE: To investigate the association of polymorphisms in the vascular endothelial growth factor (VEGF) family genes (VEGFA rs699947, VEGFA rs3025039, PGF rs1042886, KDR rs2071559 and KDR rs2305948) with preeclampsia in Sinhalese women in Sri-Lanka. METHODS: We conducted a case-control study where 175 nulliparous Sinhalese women with preeclampsia and 171 normotensive women matched for age, ethnicity, parity and BMI were recruited in tertiary care maternity hospitals in Sri-Lanka. Preeclampsia was diagnosed using international guidelines. DNA extracted from peripheral venous blood and was genotyped using the Sequenom MassARRAY system. χ2-test was used to compare the distribution of allele and genotype frequencies between the cases and the control subjects. RESULTS: The frequency of PGF rs1042886 variant allele (odds ratio (OR) 1.5, 95% confidence interval (CI) 1.1–2.1) and dominant genotype model (aOR 1.6, 95% CI 1.0–2.4) were increased in preeclamptic women compared to controls. VEGFA rs699947, VEGFA rs3025039, KDR rs2071559, and KDR rs2305948 polymorphisms were not associated with preeclampsia. CONCLUSION: Maternal PGF rs1042886 polymorphism is associated with preeclampsia in Sinhalese women in Sri-Lanka.
Keywords: VEGF; PIGF; KDR; polymorphism; preeclampsia
Rights: © 2013 Informa UK, Ltd.
RMID: 0020125363
DOI: 10.3109/14767058.2012.743520
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Appears in Collections:Obstetrics and Gynaecology publications

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