Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76328
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dc.contributor.authorGanesan, A.en
dc.contributor.authorKuklik, P.en
dc.contributor.authorLau, D.en
dc.contributor.authorBrooks, A.en
dc.contributor.authorBaumert, M.en
dc.contributor.authorLim, W.en
dc.contributor.authorThanigaimani, S.en
dc.contributor.authorNayyar, S.en
dc.contributor.authorMahajan, N.en
dc.contributor.authorKalman, J.en
dc.contributor.authorRoberts-Thomson, K.en
dc.contributor.authorSanders, P.en
dc.date.issued2013en
dc.identifier.citationCirculation. Arrhythmia and Elecrophysiology (online), 2013; 6(1):48-57en
dc.identifier.issn1941-3084en
dc.identifier.issn1941-3084en
dc.identifier.urihttp://hdl.handle.net/2440/76328-
dc.description.abstractBACKGROUND: The pivot is critical to rotors postulated to maintain atrial fibrillation (AF). We reasoned that wavefronts circling the pivot should broaden the amplitude distribution of bipolar electrograms because of directional information encoded in these signals. We aimed to determine whether Shannon entropy (ShEn), a measure of signal amplitude distribution, could differentiate the pivot from surrounding peripheral regions and thereby assist clinical rotor mapping. METHODS AND RESULTS: Bipolar electrogram recordings were studied in 4 systems: (1) computer simulations of rotors in a 2-dimensional atrial sheet; (2) isolated rat atria recorded with a multi-electrode array (n=12); (3) epicardial plaque recordings of induced AF in hypertensive sheep (n=11); and (4) persistent AF patients (n=10). In the model systems, rotation episodes were identified, and ShEn calculated as an index of amplitude distribution. In humans, ShEn distribution was analyzed at AF termination sites and with respect to complex fractionated electrogram mean. We analyzed rotation episodes in simulations (4 cycles) and animals (rats: 14 rotors, duration 80±81 cycles; sheep: 13 rotors, 4.2±1.5 cycles). The maximum ShEn bipole was consistently colocated with the pivot zone. ShEn was negatively associated with distance from the pivot zone in simulated spiral waves, rats, and sheep. ShEn was modestly inversely associated with complex fractionated electrogram; however, there was no relationship at the sites of highest ShEn. CONCLUSIONS: ShEn is a mechanistically based tool that may assist AF rotor mapping.en
dc.description.statementofresponsibilityAnand N. Ganesan, Pawel Kuklik, Dennis H. Lau, Anthony G. Brooks, Mathias Baumert, Wei Wen Lim, Shivshankar Thanigaimani, Sachin Nayyar, Rajiv Mahajan, Jonathan M. Kalman, Kurt C. Roberts-Thomson, Prashanthan Sandersen
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.rights© 2013 American Heart Association, Inc.en
dc.subjectarrhythmia; atrial fibrillation; electrophysiology; mappingen
dc.titleBipolar electrogram Shannon entropy at sites of rotational activation: implications for ablation of atrial fibrillationen
dc.typeJournal articleen
dc.identifier.rmid0020124386en
dc.identifier.doi10.1161/CIRCEP.112.976654en
dc.identifier.pubid21860-
pubs.library.collectionElectrical and Electronic Engineering publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLau, D. [0000-0001-7753-1318]en
dc.identifier.orcidBaumert, M. [0000-0003-2984-2167]en
dc.identifier.orcidThanigaimani, S. [0000-0003-0322-6147]en
dc.identifier.orcidSanders, P. [0000-0003-3803-8429]en
Appears in Collections:Electrical and Electronic Engineering publications

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