Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76398
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dc.contributor.authorDannlowski, U.en
dc.contributor.authorKugel, H.en
dc.contributor.authorHuber, F.en
dc.contributor.authorStuhrmann, A.en
dc.contributor.authorRedlich, R.en
dc.contributor.authorGrotegerd, D.en
dc.contributor.authorDohm, K.en
dc.contributor.authorSehlmeyer, C.en
dc.contributor.authorKonrad, C.en
dc.contributor.authorBaune, B.en
dc.contributor.authorArolt, V.en
dc.contributor.authorHeindel, W.en
dc.contributor.authorZwitserlood, P.en
dc.contributor.authorSuslow, T.en
dc.date.issued2013en
dc.identifier.citationHuman Brain Mapping, 2013; 34(11):2899-2909en
dc.identifier.issn1065-9471en
dc.identifier.issn1097-0193en
dc.identifier.urihttp://hdl.handle.net/2440/76398-
dc.description.abstractMajor depression has been repeatedly associated with amygdala hyper-responsiveness to negative (but not positive) facial expressions at early, automatic stages of emotion processing using subliminally presented stimuli. However, it is not clear whether this "limbic bias" is a correlate of depression or represents a vulnerability marker preceding the onset of the disease. Because childhood maltreatment is a potent risk factor for the development of major depression in later life, we explored whether childhood maltreatment is associated with amygdalar emotion processing bias in maltreated but healthy subjects. Amygdala responsiveness to subliminally presented sad and happy faces was measured by means of fMRI at 3 T in N = 150 healthy subjects carefully screened for psychiatric disorders. Childhood maltreatment was assessed by the 25-item childhood trauma questionnaire (CTQ). A strong association of CTQ-scores with amygdala responsiveness to sad, but not happy facial expressions emerged. This result was further qualified by an interaction of emotional valence and CTQ-scores and was not confounded by trait anxiety, current depression level, age, gender, intelligence, education level, and more recent stressful life-events. Childhood maltreatment is apparently associated with detectable changes in amygdala function during early stages of emotion processing which resemble findings described in major depression. Limbic hyper-responsiveness to negative facial cues could be a consequence of the experience of maltreatment during childhood increasing the risk of depression in later life.the present association of limbic bias and maltreatment was demonstrated in the absence of psychopathological abnormalities, thereby limiting strong conclusions.en
dc.description.statementofresponsibilityUdo Dannlowski, Harald Kugel, Franziska Huber, Anja Stuhrmann, Ronny Redlich, Dominik Grotegerd, Katharina Dohm, Christina Sehlmeyer, Carsten Konrad, Bernhard T. Baune, Volker Arolt, Walter Heindel, Pienie Zwitserlood and Thomas Suslowen
dc.language.isoenen
dc.publisherWiley-Lissen
dc.rightsCopyright © 2012 Wiley Periodicals, Inc.en
dc.subjectAmygdala; Humans; Magnetic Resonance Imaging; Echo-Planar Imaging; Facial Expression; Brain Mapping; Questionnaires; Data Interpretation, Statistical; Risk Factors; Regression Analysis; Depression; Emotions; Cues; Subliminal Stimulation; Social Perception; Psychomotor Performance; Child Abuse; Socioeconomic Factors; Image Processing, Computer-Assisted; Diagnostic and Statistical Manual of Mental Disorders; Adult; Middle Aged; Child; Female; Male; Young Adulten
dc.titleChildhood maltreatment is associated with an automatic negative emotion processing bias in the amygdalaen
dc.typeJournal articleen
dc.identifier.rmid0020125902en
dc.identifier.doi10.1002/hbm.22112en
dc.identifier.pubid20955-
pubs.library.collectionPsychiatry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidBaune, B. [0000-0001-6548-426X]en
Appears in Collections:Psychiatry publications

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