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https://hdl.handle.net/2440/7657
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Type: | Journal article |
Title: | Visual acuity and retinal function in infant monkeys fed long-chain PUFA |
Author: | Jeffrey, B. Mitchell, D. Hibbeln, J. Gibson, R. Chedester, A. Salem, N. |
Citation: | Lipids, 2002; 37(9):839-848 |
Publisher: | Amer Oil Chemists Soc A O C S Press |
Issue Date: | 2002 |
ISSN: | 0024-4201 1558-9307 |
Statement of Responsibility: | Brett G. Jeffrey, Drake C. Mitchell, Joseph R. Hibbeln, Robert A. Gibson, A. Lee Chedester and Norman Salem |
Abstract: | Previous randomized clinical trials suggest that supplementation of the human infant diet with up to 0.35% DHA may benefit visual development. The aim of the current study was to assess the impact of including arachidonic acid (AA) and a higher level of DHA in the postnatal monkey diet on visual development. Infant rhesus monkeys were fed either a control diet (2.0% α-linolenic acid as the sole n-3 FA) or a supplemented diet (1.0% DHA and 1.0% AA) from birth. Visual evoked potential acuity was measured at 3 mon of age. Rod and cone function were assessed in terms of parameters describing phototransduction. Electroretinogram (ERG) amplitudes and implicit times were recorded over a wide intensity range (−2.2 to 4.0 log scot td-sec) and assessed in terms of intensity response functions. Plasma DHA and AA were significantly increased (P < 0.001) in the diet-supplemented monkeys compared with the control monkeys. There was an approximately equal effect of diet for the rod phototransduction parameters, sensitivity, and capacitance but in the opposite directions. Diet-supplemented monkeys had significantly shorter b-wave implicit times at low retinal illuminances (<0.6 log scot td-sec). There were no significant effects of diet for visual acuity or the other 23 ERG parameters measured. The results suggest that supplementation of the infant monkey diet with 1.0% DHA and 1.0% AA neither harms nor provides substantial benefit to the development of visual acuity or retinal function in the first four postnatal months. |
Keywords: | Retina Animals Animals, Newborn Dietary Fats, Unsaturated Fatty Acids, Unsaturated Arachidonic Acid Electroretinography Visual Acuity Female Male Retinal Rod Photoreceptor Cells Retinal Cone Photoreceptor Cells |
Description: | The original publication can be found at www.springerlink.com |
DOI: | 10.1007/s11745-002-0969-0 |
Published version: | http://dx.doi.org/10.1007/s11745-002-0969-0 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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