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https://hdl.handle.net/2440/76820
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Type: | Journal article |
Title: | Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical |
Other Titles: | Dietary polyphenol-derived protection against neurotoxic beta-amyloid protein: from molecular to clinical |
Author: | Smid, S. Maag, J. Musgrave, I. |
Citation: | Food and Function, 2012; 3(12):1242-1250 |
Publisher: | R S C Publications |
Issue Date: | 2012 |
ISSN: | 2042-6496 2042-650X |
Statement of Responsibility: | Scott D. Smid, Jesper L. Maag and Ian F. Musgrave |
Abstract: | Polyphenolic compounds derived mainly from plant products have demonstrated neuroprotective properties in a number of experimental settings. Such protective effects have often been ascribed to antioxidant capacity, but specific augmentation of other cellular defences and direct interactions with neurotoxic proteins have also been demonstrated. With an emphasis on neurodegenerative conditions, such as Alzheimer's disease, we highlight recent findings on the neuroprotection ascribed to bioactive polyphenols capable of directly interfering with the Alzheimer's disease hallmark toxic β-amyloid protein (Aβ), thereby inhibiting fibril and aggregate formation. This includes compounds such as the green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) and the phytoalexin resveratrol. Targeted studies on the biomolecular interactions between dietary polyphenolics and Aβ have not only improved our understanding of the pathogenic role of β-amyloid, but also offer fundamentally novel treatment options for Alzheimer's disease and potentially other amyloidoses. |
Keywords: | Neurons Cell Line Humans Plants Alzheimer Disease Neurodegenerative Diseases Curcumin Stilbenes Catechin Neuroprotective Agents Antioxidants Diet Models, Molecular Tea Amyloid beta-Peptides Polyphenols Resveratrol |
Rights: | This journal is © The Royal Society of Chemistry 2012 |
DOI: | 10.1039/c2fo30075c |
Published version: | http://dx.doi.org/10.1039/c2fo30075c |
Appears in Collections: | Aurora harvest Pharmacology publications |
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