Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7687
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Digoxin-like immunoreactivity in early infant death |
Author: | Couper, R. Aldis, J. Byard, R. |
Citation: | Medicine Science and the Law, 1998; 38(1):52-56 |
Publisher: | CHILTERN PUBLISHING |
Issue Date: | 1998 |
ISSN: | 0025-8024 2042-1818 |
Abstract: | The aim of this study was to determine if the level of digoxin-like immunoreactivity in post-mortem sera obtained from infants differs according to the cause of death and if the level is related to age, post-mortem interval, cardiac pathology or adrenal weight. Twelve infants whose deaths were attributed to sudden infant death syndrome (SIDS), and 11 infants who died from other causes, had blood sampled between 3 to 53 hours post-mortem from their right atrial cavity. Digoxin-like immunoreactivity was measured, using a specific and sensitive digoxin radioimmunoassay, and was detected in 7 of the infants who died of SIDS and 7 of those who died from other causes. The highest levels were seen in two patients who died from meningococcal sepsis and haemorrhage, hyperpyrexia and encephalopathy syndrome, respectively. No correlation was detected between the digoxin-like immunoreactivity level, gender, age at death, post-mortem interval or cardiac pathology. Digoxin-like immunoreactivity levels correlated with adrenal weight. It is concluded that digoxin-like immunoreactivity is frequently found in infant sera, but levels are not specific to and are no higher in SIDS infants than infants dying of other conditions. |
Keywords: | Humans Sudden Infant Death Cardenolides Digoxin Saponins Enzyme Inhibitors Linear Models Case-Control Studies Infant Female Male Sodium-Potassium-Exchanging ATPase |
DOI: | 10.1177/002580249803800108 |
Published version: | http://dx.doi.org/10.1177/002580249803800108 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.