Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/77422
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Mesenteric blood flow, glucose absorption and blood pressure responses to small intestinal glucose in critically ill patients older than 65 years
Author: Sim, J.
Horowitz, M.
Summers, M.
Trahair, L.
Goud, R.
Zaknic, A.
Hausken, T.
Fraser, J.
Chapman, M.
Jones, K.
Deane, A.
Citation: Intensive Care Medicine, 2013; 39(2):258-266
Publisher: Springer
Issue Date: 2013
ISSN: 0342-4642
1432-1238
Statement of
Responsibility: 
Jennifer A. Sim, M. Horowitz, M. J. Summers, L. G. Trahair, R. S. Goud, A. V. Zaknic, T. Hausken, J. D. Fraser, M. J. Chapman, K. L. Jones, A. M. Deane
Abstract: To compare nutrient-stimulated changes in superior mesenteric artery (SMA) blood flow, glucose absorption and glycaemia in individuals older than 65 years with, and without, critical illness.Following a 1-h 'observation' period (t (0)-t (60)), 0.9 % saline and glucose (1 kcal/ml) were infused directly into the small intestine at 2 ml/min between t (60)-t (120), and t (120)-t (180), respectively. SMA blood flow was measured using Doppler ultrasonography at t (60) (fasting), t (90) and t (150) and is presented as raw values and nutrient-stimulated increment from baseline (Δ). Glucose absorption was evaluated using serum 3-O-methylglucose (3-OMG) concentrations during, and for 1 h after, the glucose infusion (i.e. t (120)-t (180) and t (120)-t (240)). Mean arterial pressure was recorded between t (60)-t (240). Data are presented as median (25th, 75th percentile).Eleven mechanically ventilated critically ill patients [age 75 (69, 79) years] and nine healthy volunteers [70 (68, 77) years] were studied. The magnitude of the nutrient-stimulated increase in SMA flow was markedly less in the critically ill when compared with healthy subjects [Δt (150): patients 115 (-138, 367) versus health 836 (618, 1,054) ml/min; P = 0.001]. In patients, glucose absorption was reduced during, and for 1 h after, the glucose infusion when compared with health [AUC(120-180): 4.571 (2.591, 6.551) versus 11.307 (8.447, 14.167) mmol/l min; P < 0.001 and AUC(120-240): 26.5 (17.7, 35.3) versus 40.6 (31.7, 49.4) mmol/l min; P = 0.031]. A close relationship between the nutrient-stimulated increment in SMA flow and glucose absorption was evident (3-OMG AUC(120-180) and ∆SMA flow at t (150): r (2) = 0.29; P < 0.05).In critically ill patients aged >65 years, stimulation of SMA flow by small intestinal glucose infusion may be attenuated, which could account for the reduction in glucose absorption.
Keywords: Critical illness; Superior mesenteric artery; Glucose absorption; Nutrition; Postprandial hypotension; Splanchnic blood flow
Rights: © Springer-Verlag Berlin Heidelberg and ESICM 2012
RMID: 0020125626
DOI: 10.1007/s00134-012-2719-5
Grant ID: http://purl.org/au-research/grants/nhmrc/1025648
Appears in Collections:Anaesthesia and Intensive Care publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.