Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/77632
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Type: Journal article
Title: Incidence of metastatic breast cancer in an Australian population-based cohort of women with non-metastatic breast cancer at diagnosis
Author: Lord, S.
Marinovich, M.
Patterson, J.
Wilcken, N.
Kiely, B.
Gebski, V.
Crossing, S.
Roder, D.
Gattellari, M.
Houssami, N.
Citation: Medical Journal of Australia, 2012; 196(11):688-692
Publisher: Australasian Med Publ Co Ltd
Issue Date: 2012
ISSN: 0025-729X
1326-5377
Statement of
Responsibility: 
Sarah J. Lord, M. Luke Marinovich, Jillian A. Patterson, Nicholas Wilcken, Belinda E. Kiely, Val Gebski, Sally Crossing, David M. Roder, Melina Gattellari and Hehmat Houssami
Abstract: OBJECTIVES: To estimate the incidence of metastatic breast cancer (MBC) in Australian women with an initial diagnosis of non-metastatic breast cancer. Design, setting and participants: A population-based cohort study of all women with non-metastatic breast cancer registered on the New South Wales Central Cancer Register (CCR) in 2001 and 2002 who received care in a NSW hospital. MAIN OUTCOME MEASURES: 5-year cumulative incidence of MBC; prognostic factors for MBC. RESULTS: MBC was recorded within 5 years in 218 of 4137 women with localised node-negative disease (5-year cumulative incidence, 5.3%; 95% CI, 4.6%– 6.0%); and 455 of 2507 women with regional disease (5-year cumulative incidence, 18.1%; 95% CI, 16.7%–19.7%). The hazard rate for developing MBC was highest in the second year after the initial diagnosis of breast cancer. Determinants of increased risk of MBC were regional disease at diagnosis, age less than 50 years and living in an area of lower socio-economic status. CONCLUSIONS: Our Australian population-based estimates are valuable when communicating average MBC risks to patients and planning clinical services and trials. Women with node-negative disease have a low risk of developing MBC, consistent with outcomes of adjuvant clinical trials. Regional disease at diagnosis remains an important prognostic factor.
Keywords: Humans; Breast Neoplasms; Neoplasm Metastasis; Early Diagnosis; Prognosis; Incidence; Multivariate Analysis; Proportional Hazards Models; Risk Factors; Cohort Studies; Aged; Middle Aged; Rural Population; New South Wales; Female; Kaplan-Meier Estimate
Rights: Copyright status unknown
RMID: 0020127283
DOI: 10.5694/mja12.10026
Appears in Collections:Public Health publications

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