Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/77668
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, C. | - |
dc.contributor.author | Kostakis, C. | - |
dc.contributor.author | Irvine, R. | - |
dc.contributor.author | Felgate, P. | - |
dc.contributor.author | White, J. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Drug Testing and Analysis, 2013; 5(8):716-721 | - |
dc.identifier.issn | 1942-7611 | - |
dc.identifier.issn | 1942-7611 | - |
dc.identifier.uri | http://hdl.handle.net/2440/77668 | - |
dc.description | Article first published online: 9 OCT 2012 | - |
dc.description.abstract | Wastewater analysis has the potential to provide objective and timely data on population drug consumption, but some crucial factors such as pre-analysis drug loss during sample storage and filtration could affect the accuracy and reliability of the method, and these uncertainties have yet to be fully assessed. This study was designed to evaluate analyte stability in wastewater stored under different conditions with the aim of optimizing the sample storage procedures for future studies. It also investigated whether there is significant analyte loss during filtration before sample extraction and storage after that. The studied substances and metabolites were: cotinine, cocaine and its metabolite benzoylecgonine, phenethylamines amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), opioids including codeine, methadone, 6-monoacetylmorphine (MAM) and morphine. In most situations, storing samples at 4 °C is sufficient to stabilize analytes for at least 2 weeks, and refrigeration is unnecessary during sample transportation within 3 days. However, additional measures need to be taken if unstable analytes such as cocaine and MAM are to be analyzed. No significant analyte loss was observed in the filtration process or in reconstituted extract stored at 4 °C or -20 °C for 2 weeks. By choosing stable analytes and proper storage conditions, wastewater analysis has the potential to provide accurate data for estimation of community drug use. | - |
dc.description.statementofresponsibility | Chang Chen, Chris Kostakis, Rodney J. Irvine, Peter D. Felgate and Jason M. White | - |
dc.language.iso | en | - |
dc.publisher | John Wiley & Sons Ltd | - |
dc.rights | Copyright © 2012 John Wiley & Sons, Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1002/dta.1428 | - |
dc.subject | Amphetamine | - |
dc.subject | Methamphetamine | - |
dc.subject | N-Methyl-3,4-methylenedioxyamphetamine | - |
dc.subject | Morphine | - |
dc.subject | Morphine Derivatives | - |
dc.subject | Codeine | - |
dc.subject | Cocaine | - |
dc.subject | Cotinine | - |
dc.subject | Water Pollutants, Chemical | - |
dc.subject | Chromatography, Liquid | - |
dc.subject | Drug Stability | - |
dc.subject | Tandem Mass Spectrometry | - |
dc.subject | Liquid-Liquid Extraction | - |
dc.subject | Illicit Drugs | - |
dc.subject | Wastewater | - |
dc.title | Evaluation of pre-analysis loss of dependent drugs in wastewater: stability and binding assessments | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/dta.1428 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 4 Pharmacology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.