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Type: Journal article
Title: A randomised controlled trial of sublingual buprenorphine-naloxone film versus tablets in the management of opioid dependence
Author: Lintzeris, N.
Leung, S.
Dunlop, A.
Larance, B.
White, N.
Rivas, G.
Holland, R.
Degenhardt, L.
Muhleisen, P.
Hurley, M.
Ali, R.
Citation: Drug and Alcohol Dependence, 2013; 131(1-2):119-126
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2013
ISSN: 0376-8716
Statement of
N. Lintzeris, S.Y. Leung, A.J. Dunlop, B. Larance, N. White, G.R. Rivas, R.M. Holland, L. Degenhardt, P. Muhleisen, M. Hurley, R. Ali
Abstract: BACKGROUND: Buprenorphine-naloxone sublingual film was introduced in 2011 in Australia as an alternative to tablets. This study compared the two formulations on subjective dose effects and equivalence, trough plasma levels, adverse events, patient satisfaction, supervised dosing time, and impact upon treatment outcomes (substance use, psychosocial function). METHODS: 92 buprenorphine-naloxone tablet patients were recruited to this outpatient multi-site double-blind double-dummy parallel group trial. Patients were randomised to either tablets or film, without dose changes, over a 31 day period. RESULTS: No significant group differences were observed for subjective dose effects, trough plasma buprenorphine or norbuprenorphine levels, adverse events and treatment outcomes. Buprenorphine-naloxone film took significantly less time to dissolve than tablets (173±71 versus 242±141s, p=0.007, F=7.67). CONCLUSIONS: The study demonstrated dose equivalence and comparable clinical outcomes between the buprenorphine-naloxone film and tablet preparations, whilst showing improved dispensing times and patient ratings of satisfaction with the film.
Keywords: Buprenorphine–naloxone film; Buprenorphine–naloxone tablets; Opioid dependency; Opioid substitution therapy; Randomised controlled trial
Rights: Copyright © 2013 Elsevier Ireland Ltd.
RMID: 0020124870
DOI: 10.1016/j.drugalcdep.2012.12.009
Appears in Collections:Pharmacology publications

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