Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/78515
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dc.contributor.authorGiles, L.en
dc.contributor.authorWhitrow, M.en
dc.contributor.authorRumbold, A.en
dc.contributor.authorDavies, C.en
dc.contributor.authorDe Stavola, B.en
dc.contributor.authorPitcher, J.en
dc.contributor.authorDavies, M.en
dc.contributor.authorMoore, V.en
dc.date.issued2013en
dc.identifier.citationInternational Journal of Obesity, 2013; 37(4):513-519en
dc.identifier.issn0307-0565en
dc.identifier.issn1476-5497en
dc.identifier.urihttp://hdl.handle.net/2440/78515-
dc.description.abstractOBJECTIVE: Rapid growth, possibly occurring in critical periods in early life, may be important for the development of obesity. It is unknown whether this is influenced by postnatal exposures such as age-relevant sources of stress. Frequent house moves may be one such stressor. We aimed to examine if there is a period of growth in early life critical for the development of child obesity by age 9 years and assess the role of house moves in modifying any relationships between early life growth and obesity at age 9 years. DESIGN: Prospective Australian birth cohort study. SUBJECTS: In all, 392 children with serial body size measurements from birth to age 9 years. METHODS: Standardized body mass index (z-BMI) was available for six time points (spanning birth to 3½ years), and the total number of house moves between birth and 3½ years. The outcomes considered were z-BMI and % body fat (%BF) at age 9 years. Linear regression models were used to estimate the effects of serial measurements of z-BMI and number of house moves on the outcomes. RESULTS: Life-course plots showed that z-BMI at 3½ years was a statistically significant predictor of z-BMI at 9 years (b¼0.80; standard error (s.e.), 0.04), whereas z-BMI at 9 months (ᵦ_1.13; s.e., 0.40) and 3½ years (b¼4.82; s.e., 0.42) were significant predictors of %BF at age 9 years. There were statistically significant interactions between the number of house moves and change in z-BMI between 9 and 12 months, such that X3 house moves in early life amplified the detrimental effects of earlier rapid growth on both body size and composition at age 9 years. CONCLUSION: In the absence of evidence for a single critical period, efforts to prevent overweight and obesity are required throughout childhood. In addition, modifiable postnatal stressors may exacerbate effects of early growth on obesity in later childhood.en
dc.description.statementofresponsibilityL.C. Giles, M.U. Whitrow, A.R. Rumbold, C.E. Davies, B. de Stavola, J.B. Pitcher, M.J. Davies and V.M. Mooreen
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2013 Macmillan Publishers Limiteden
dc.subjectEarly childhood; growth; residential mobility; stressorsen
dc.titleGrowth in early life and the development of obesity by age 9 years: are there critical periods and a role for an early life stressor?en
dc.typeJournal articleen
dc.identifier.rmid0020124858en
dc.identifier.doi10.1038/ijo.2012.219en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/465455en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/465437en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/349548en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627033en
dc.identifier.pubid21558-
pubs.library.collectionPublic Health publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGiles, L. [0000-0001-9054-9088]en
dc.identifier.orcidRumbold, A. [0000-0002-4453-9425]en
dc.identifier.orcidDavies, C. [0000-0001-6595-8656]en
dc.identifier.orcidPitcher, J. [0000-0002-9648-7540]en
dc.identifier.orcidDavies, M. [0000-0003-1526-0801]en
dc.identifier.orcidMoore, V. [0000-0001-9505-6450]en
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