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https://hdl.handle.net/2440/7920
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dc.contributor.author | Kind, K. | - |
dc.contributor.author | Owens, J. | - |
dc.contributor.author | Lok, F. | - |
dc.contributor.author | Robinson, J. | - |
dc.contributor.author | Quinn, K. | - |
dc.contributor.author | Mundy, L. | - |
dc.contributor.author | Gilmour, R. | - |
dc.contributor.author | Owens, P. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | American Journal of Physiology, 1996; 271(6):R1632-R1637 | - |
dc.identifier.issn | 0002-9513 | - |
dc.identifier.issn | 1522-1490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7920 | - |
dc.description.abstract | Liver contains the highest concentrations of insulin-like growth factor (IGF) I mRNA in adult rats and sheep and is a major source of circulating IGF-I. In rats, inhibition of hepatic IGF-I production by exogenous IGF-I has been reported. In fetal sheep, skeletal muscle and liver are major sites of IGF-I synthesis and potential sources of circulating IGF-I. To determine whether feedback inhibition of IGF gene expression in fetal liver or muscle by IGF-I occurs, IGF-I and IGF-II mRNAs were measured in these tissues after intravenous infusion of recombinant human IGF-I into fetal sheep. Infusion of IGF-I (26 +/- 4 micrograms.h-1.kg-1; n = 6) or saline (n = 6) commenced on day 120 of pregnancy (term = 150 days) and continued for 10 days. Plasma concentrations of IGF-I were threefold higher in infused fetuses at 130 days of gestation (P < 0.0003), whereas those of IGF-II were unchanged. IGF-I infusion reduced the relative abundance of IGF-I mRNA (P < 0.0002) and IGF-II mRNA (P < 0.01) in fetal liver by approximately 50% but did not alter IGF-I or IGF-II mRNA in skeletal muscle. These results indicate that IGF-I inhibits the expression of both IGF-I and IGF-II genes in fetal liver and that IGF gene expression in fetal liver and muscle is differentially regulated by IGF-I. | - |
dc.description.statementofresponsibility | Karen L. Kind, Julie A. Owens, Fong, Lok, Jeffrey S. Robinson, Kirsty J. Quinn, Linda Mundy, R. Stewart Gilmour, and Phillip C. Owens | - |
dc.language.iso | en | - |
dc.publisher | American Physiological Society | - |
dc.rights | Copyright © 1996 the American Physiological Society | - |
dc.source.uri | http://ajpregu.physiology.org/content/271/6/R1632 | - |
dc.subject | Liver | - |
dc.subject | Fetal Blood | - |
dc.subject | Fetus | - |
dc.subject | Animals | - |
dc.subject | Sheep | - |
dc.subject | Humans | - |
dc.subject | Insulin | - |
dc.subject | Blood Glucose | - |
dc.subject | Insulin-Like Growth Factor I | - |
dc.subject | Insulin-Like Growth Factor II | - |
dc.subject | Insulin-Like Growth Factor Binding Proteins | - |
dc.subject | Recombinant Proteins | - |
dc.subject | RNA, Messenger | - |
dc.subject | Blotting, Western | - |
dc.subject | Infusions, Intravenous | - |
dc.subject | Female | - |
dc.title | Intravenous infusion of insulin-like growth factor I in fetal sheep reduces hepatic IGF-I and IGF-II mRNAs | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.1996.271.6.r1632 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Owens, J. [0000-0002-7498-1353] | - |
dc.identifier.orcid | Robinson, J. [0000-0002-4515-6039] | - |
dc.identifier.orcid | Mundy, L. [0000-0002-7874-4232] | - |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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