Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7928
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferguson, S. | - |
dc.contributor.author | Kennaway, D. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 1999; 277(4 46-4):R1171-R1178 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.issn | 2163-5773 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7928 | - |
dc.description.abstract | Mammalian circadian rhythms are controlled by the suprachiasmatic nuclei (SCN) in concert with light information. Several neurotransmitters and neural pathways modulate light effects on SCN timing. This study used a line of rat with an upregulated cholinergic system to investigate the role of acetylcholine in rhythmicity. With the use of a selective breeding program based on the thermic response to a cholinergic agonist, we developed a supersensitive (S(ox)) and subsensitive (R(ox)) rat line. The S(ox) rats showed an earlier onset time of melatonin rhythm under a 12:12-h light-dark photoperiod from generation 3 (3 +/- 0.5 h after dark) compared with R(ox) rats (4.5 +/- 0.1 h) and an earlier morning decline in temperature (0.9 +/- 0.3 h before lights on) compared with R(ox) animals (0.1 +/- 0.1 h). Furthermore, the S(ox) animals displayed a significantly shorter free-running period of temperature rhythm than R(ox) rats (23.9 +/- 0.04 and 24.3 +/- 0.1 h, respectively, P < 0.05). The results suggest that the altered circadian timing of the S(ox) rats may be related to the cholinergic supersensitivity, intimating a role for acetylcholine in the circadian timing system. | - |
dc.language.iso | en | - |
dc.publisher | AMER PHYSIOLOGICAL SOC | - |
dc.source.uri | http://dx.doi.org/10.1152/ajpregu.1999.277.4.r1171 | - |
dc.subject | Suprachiasmatic Nucleus | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Acetylcholine | - |
dc.subject | Oxotremorine | - |
dc.subject | Melatonin | - |
dc.subject | Proto-Oncogene Proteins c-fos | - |
dc.subject | Cholinergic Agents | - |
dc.subject | Muscarinic Agonists | - |
dc.subject | Body Temperature | - |
dc.subject | Circadian Rhythm | - |
dc.subject | Drug Resistance | - |
dc.subject | Light | - |
dc.subject | Darkness | - |
dc.title | Emergence of altered circadian timing in a cholinergically supersensitive rat line | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.1999.277.4.r1171 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kennaway, D. [0000-0002-5864-3514] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.