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https://hdl.handle.net/2440/7936
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dc.contributor.author | Robertson, S. | - |
dc.contributor.author | Mau, V. | - |
dc.contributor.author | Hudson, S. | - |
dc.contributor.author | Tremellen, K. | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | American Journal of Reproductive Immunology, 1997; 37(6):438-442 | - |
dc.identifier.issn | 8755-8920 | - |
dc.identifier.issn | 1600-0897 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7936 | - |
dc.description.abstract | PROBLEM: Factors in seminal plasma stimulate an intense but transient inflammatory response in the murine endometrium at mating. The aim of our current studies is to delineate the cytokine-leukocyte interactions comprising this response and to elucidate the significance of these events in changes in the maternal immune system and as determinants of pregnancy outcome. METHOD: We have reviewed our recent findings. RESULTS: Transforming growth factor (TGF)-β1 has been identified as the inflammation-inducing moiety in seminal plasma. Seminal TGFβ1 initiates endometrial leukocyte infiltration by up-regulating epithelial cell expression of granulocyte-macrophage colony-stimulating factor. Other cytokines and chemokines including regulated and normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1α, MIP-1β, and monocyte chemotactic protein-1 are also implicated as mediators of macrophage and granulocyte recruitment and activation. One consequence of this inflammatory response is the induction of a transient state of hyporesponsiveness to paternal major histocompatibility class I antigens. CONCLUSION: Our studies suggest that semen may play a critical role in providing the antigenic and environmental signals necessary to initiate an appropriate maternal immune response to the conceptus during pregnancy. | - |
dc.description.statementofresponsibility | Sarah A. Robertson, Vicki J. Mau, Sarah N. Hudson, Kelton P. Tremellen | - |
dc.language.iso | en | - |
dc.publisher | MUNKSGAARD INT PUBL LTD | - |
dc.rights | © 1997 Munksgaard | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1600-0897.1997.tb00257.x | - |
dc.subject | GM-CSF | - |
dc.subject | macrophage | - |
dc.subject | seminal plasma | - |
dc.subject | TGFβ tolerance | - |
dc.subject | uterus | - |
dc.title | Cytokine-leukocyte networks and the establishment of pregnancy | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1600-0897.1997.tb00257.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Robertson, S. [0000-0002-9967-0084] | - |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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