Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79886
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Type: Journal article
Title: Neuroinflammation: beneficial and detrimental effects after traumatic brain injury
Author: Finnie, J.
Citation: Inflammopharmacology, 2013; 21(4):309-320
Publisher: Kluwer Academic Publ
Issue Date: 2013
ISSN: 0925-4692
1568-5608
Statement of
Responsibility: 
J. W. Finnie
Abstract: Traumatic brain injury (TBI) is the major cause of death and severe disability in young adults and infants worldwide and many survivors also have mild to moderate neurological deficits which impair their lives. This review highlights the primary and secondary lesions constituting craniocerebral trauma and the main elements of neuroinflammation, one of the most important secondary events evolving after the initial traumatic insult. Neuroinflammation has dual and opposing roles in outcome after TBI, being both beneficial and harmful, its effects often differing between the acute and more delayed phases after injury. Since each patient with TBI has a unique and complex pattern of cerebral damage, developing pharmacological intervention strategies targeted at the multiple cellular and molecular events in the neuroinflammatory cascade is difficult. While there have been very few successful outcomes to date in human clinical trials of drugs developed to treat TBI in general, those that have been devised to modulate neuroinflammation are discussed.
Keywords: Traumatic brain injury; Neuroinflammation; Pharmacotherapeutics
Rights: Copyright status unknown
RMID: 0020130757
DOI: 10.1007/s10787-012-0164-2
Appears in Collections:Pathology publications

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