Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79886
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dc.contributor.authorFinnie, J.en
dc.date.issued2013en
dc.identifier.citationInflammopharmacology, 2013; 21(4):309-320en
dc.identifier.issn0925-4692en
dc.identifier.issn1568-5608en
dc.identifier.urihttp://hdl.handle.net/2440/79886-
dc.description.abstractTraumatic brain injury (TBI) is the major cause of death and severe disability in young adults and infants worldwide and many survivors also have mild to moderate neurological deficits which impair their lives. This review highlights the primary and secondary lesions constituting craniocerebral trauma and the main elements of neuroinflammation, one of the most important secondary events evolving after the initial traumatic insult. Neuroinflammation has dual and opposing roles in outcome after TBI, being both beneficial and harmful, its effects often differing between the acute and more delayed phases after injury. Since each patient with TBI has a unique and complex pattern of cerebral damage, developing pharmacological intervention strategies targeted at the multiple cellular and molecular events in the neuroinflammatory cascade is difficult. While there have been very few successful outcomes to date in human clinical trials of drugs developed to treat TBI in general, those that have been devised to modulate neuroinflammation are discussed.en
dc.description.statementofresponsibilityJ. W. Finnieen
dc.language.isoenen
dc.publisherKluwer Academic Publen
dc.rightsCopyright status unknownen
dc.subjectTraumatic brain injury; Neuroinflammation; Pharmacotherapeuticsen
dc.titleNeuroinflammation: beneficial and detrimental effects after traumatic brain injuryen
dc.typeJournal articleen
dc.identifier.rmid0020130757en
dc.identifier.doi10.1007/s10787-012-0164-2en
dc.identifier.pubid18709-
pubs.library.collectionPathology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Pathology publications

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