Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/80204
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dc.contributor.authorBrotherton, P.en
dc.contributor.authorHaak, W.en
dc.contributor.authorTempleton, J.en
dc.contributor.authorSoubrier, J.en
dc.contributor.authorAdler, C.en
dc.contributor.authorRichards, S.en
dc.contributor.authorDersarkissian, C.en
dc.contributor.authorCooper, A.en
dc.date.issued2013en
dc.identifier.citationNature Communications, 2013; 4(1764):1-11en
dc.identifier.issn2041-1723en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://hdl.handle.net/2440/80204-
dc.description.abstractHaplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (~5450 BC) and Bronze Age (~2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (~4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (~2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.en
dc.description.statementofresponsibilityPaul Brotherton, Wolfgang Haak, Jennifer Templeton, Guido Brandt, Julien Soubrier, Christina Jane Adler, Stephen M. Richards, Clio Der Sarkissian, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Mannis van Oven, Rosalie Kenyon, Mark B. Van der Hoek, Jonas Korlach, Khai Luong, Simon Y.W. Ho, Lluis Quintana-Murci, Doron M. Behar, Harald Meller, Kurt W. Alt, Alan Cooper & The Genographic Consortiumen
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2013 Macmillan Publishers Limited. All rights reserveden
dc.subjectGenographic Consortium; Humans; Sequence Analysis, DNA; Genetics, Population; Demography; Evolution, Molecular; Phylogeny; Base Sequence; Haplotypes; Genome, Human; Principal Component Analysis; Time Factors; Molecular Sequence Data; European Continental Ancestry Group; Genome, Mitochondrialen
dc.titleNeolithic mitochondrial haplogroup H genomes and the genetic origins of Europeansen
dc.typeJournal articleen
dc.identifier.rmid0020127464en
dc.identifier.doi10.1038/ncomms2656en
dc.relation.granthttp://purl.org/au-research/grants/arc/LP0882622en
dc.identifier.pubid20150-
pubs.library.collectionAustralian Centre for Ancient DNA publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHaak, W. [0000-0003-2475-2007]en
dc.identifier.orcidSoubrier, J. [0000-0001-9350-7369]en
dc.identifier.orcidRichards, S. [0000-0002-0202-9654]en
dc.identifier.orcidCooper, A. [0000-0002-7738-7851]en
Appears in Collections:Australian Centre for Ancient DNA publications

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