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Type: Journal article
Title: Correlation of cell disruption with homogeniser valve pressure gradient determined by computational fluid dynamics
Author: Kleinig, A.
Middelberg, A.
Citation: Chemical Engineering Science, 1996; 51(23):5103-5110
Issue Date: 1996
ISSN: 0009-2509
Abstract: Numerical investigations of the flow and pressure fields within a homogenizer valve have been conducted using the computational fluid dynamics code, PHOENICS 2.1. Results are obtained for two valve seat designs over a range of valve gaps. The dependence of valve gap on operating pressure is measured experimentally and compares well with numerical predictions. A simple expression that uses the numerical results and allows ready calculation of pressure gradient from homogenizer operating and design conditions is presented. Pressure gradient is shown to be a better independent variable for correlating cell disruption than operating pressure over a wide range of operating and design parameters.
DOI: 10.1016/S0009-2509(96)00354-5
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Chemical Engineering publications

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