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Type: Journal article
Title: Caspase-2 as a tumour suppressor
Author: Puccini, J.
Dorstyn, L.
Kumar, S.
Citation: Cell Death and Differentiation, 2013; 20(9):1133-1139
Publisher: Nature Publishing Group
Issue Date: 2013
ISSN: 1350-9047
Statement of
J Puccini, L Dorstyn and S Kumar
Abstract: Ever since its discovery 20 years ago, caspase-2 has been enigmatic and its function somewhat controversial. Although many in vitro studies suggested that caspase-2 was important for apoptosis, demonstrating an in vivo cell death role for this caspase has been more problematic, with caspase-2-deficient mice showing limited, tissue-specific cell death defects. Recent results from different laboratories suggest that at least one of its physiological roles in animals is to protect against cellular stress and transformation. As such, loss of caspase-2 augments tumorigenesis in some mouse models of cancer, assigning a tumour suppressor function to this enigmatic caspase. This review focuses on this seemingly non-apoptotic function of caspase-2 as a tumour suppressor and reconciles some of the recent findings in the field.
Keywords: caspase-2; cancer; genomic instability; tumour suppression; DNA damage response
Rights: © 2013 Macmillan Publishers Limited All rights
RMID: 0020131417
DOI: 10.1038/cdd.2013.87
Appears in Collections:Medicine publications

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