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Type: Journal article
Title: Modelling carbon dioxide molecule interacting with aquaglyceroporin and aquaporin-1 channels
Author: Garalleh, H.
Thamwattana, N.
Cox, B.
Hill, J.
Citation: Journal of Mathematical Chemistry, 2013; 51(9):2317-2327
Publisher: Baltzer Sci Publ BV
Issue Date: 2013
ISSN: 0259-9791
Statement of
Hakim Al Garalleh, Ngamta Thamwattana, Barry J. Cox, James M. Hill
Abstract: Aquaporin (AQP) is a family of membrane proteins that enable water and small individual molecules to permeate cell membranes. Examples of these protein channels are aquaglyceroporin and aquaporin-1 (AQP1). Here, we investigate the permeability of carbon dioxide (CO2) through both aquglyceroporin and AQP1 channels and explain their selectivity mechanisms. We provide a mathematical model which determines the molecular interaction potential between carbon dioxide molecule and an AQP channel. We evaluate this interaction using two approaches, namely discrete-continuum and completed discrete approaches. Both calculations agree well and our results indicate the acceptance of (CO2) molecule into these channels which is in good agreement with other recent studies. © 2013 Springer Science+Business Media New York.
Keywords: Aquaporins (AQPs)
Aquaporin-1 (AQP1)
Aquaglyceroporin (GlpF)
Lennard–Jones potential
Van der Waals interaction
Carbon dioxide
Rights: © Springer Science+Business Media New York 2013
DOI: 10.1007/s10910-013-0240-x
Grant ID: ARC
Published version:
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Mathematical Sciences publications

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