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https://hdl.handle.net/2440/8157
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Type: | Journal article |
Title: | Searching for preeclampsia genes: the current position |
Author: | Lachmeijer, A. Dekker, G. Pals, G. Aarnoudse, J. ten Kate, L. Arngrimsson, R. |
Citation: | European Journal of Obstetrics Gynecology and Reproductive Biology, 2002; 105(2):94-113 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2002 |
ISSN: | 0301-2115 1872-7654 |
Statement of Responsibility: | Augusta M. A. Lachmeijer, Guustaaf A. Dekker, Gerard Pals, Jan G. Aarnoudse, Leo P. ten Kate, and Reynir Arngrímsson |
Abstract: | Although there is substantial evidence that preeclampsia has a genetic background, the complexity of the processes involved and the fact that preeclampsia is a maternal–fetal phenomenon does not make the search for the molecular basis of preeclampsia genes easy. It is possible that the single phenotype ‘preeclampsia’ in fact should be divided into different sub-groups on genetic or biochemical level. In the present review, the preeclampsia phenotype and its pathophysiologic features are discussed. Family studies and postulated inheritance models are summarized. A systematic overview is given on the numerous candidate gene studies and gene-expression studies performed so far and on the currently available genome-wide scan data. Despite extensive research the molecular genetic basis of preeclampsia remains unclear. Future studies will hopefully enhance our insights in the molecular pathogenesis of preeclampsia |
Keywords: | Preeclampsia Pathogenesis Genetics Linkage Phenotype |
Description: | Copyright © 2002 Elsevier Science Ireland Ltd. All rights reserved. |
DOI: | 10.1016/S0301-2115(02)00208-7 |
Description (link): | http://www.sciencedirect.com/science/journal/03012115 |
Published version: | http://dx.doi.org/10.1016/s0301-2115(02)00208-7 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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