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https://hdl.handle.net/2440/81631
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Type: | Journal article |
Title: | Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro |
Other Titles: | Acai (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against beta-amyloid exposure in vitro |
Author: | Wong, D. Musgrave, I. Harvey, B. Smid, S. |
Citation: | Neuroscience Letters, 2013; 556:221-226 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2013 |
ISSN: | 0304-3940 1872-7972 |
Statement of Responsibility: | Daphne Yiu San Wong, Ian Francis Musgrave, Benjamin Scott Harvey, Scott Darryl Smid |
Abstract: | The native South American palm açaí berry (Euterpe oleraceae Mart.) has high polyphenolic and antioxidant levels. This study examined whether açaí berry extract afforded protection against β-amyloid (Aβ)-mediated loss of cell viability and oxidative stress associated with anti-fibrillar effects. PC12 cells were exposed to either Aβ1-42, Aβ25-35 or tert butyl hydroperoxide (t-BHP), alone or in the presence of açaí extract (0.5-50μg/ml). Thioflavin T (ThT) binding assay and transmission electron microscopy were used to determine effects of açaí extract on Aβ1-42 fibril morphology and compared to açaí phenolics gallic acid, cyanidin rutinoside and cyanidin glucoside. Exposure to Aβ1-42, Aβ25-35 or t-BHP decreased PC12 cell viability. Pretreatment with açaí extract significantly improved cell viability following Aβ1-42 exposure, however Aβ25-35 or t-BHP-mediated viability loss was unaltered. Açaí extract inhibited ThT fluorescence and disrupted Aβ1-42 fibril and aggregate morphology. In comparison with other phenolics, açaí was most effective at inhibiting Aβ1-42 aggregation. Inhibition of β-amyloid aggregation may underlie a neuroprotective effect of açaí. |
Keywords: | Açaí Amyloid-β Cyanidin glucoside Cyanidin rutinoside Gallic acid Oxidative stress |
Rights: | © 2013 Elsevier Ireland Ltd. |
DOI: | 10.1016/j.neulet.2013.10.027 |
Published version: | http://dx.doi.org/10.1016/j.neulet.2013.10.027 |
Appears in Collections: | Aurora harvest Pharmacology publications |
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