Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/81631
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Type: Journal article
Title: Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro
Other Titles: Acai (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against beta-amyloid exposure in vitro
Author: Wong, D.
Musgrave, I.
Harvey, B.
Smid, S.
Citation: Neuroscience Letters, 2013; 556:221-226
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2013
ISSN: 0304-3940
1872-7972
Statement of
Responsibility: 
Daphne Yiu San Wong, Ian Francis Musgrave, Benjamin Scott Harvey, Scott Darryl Smid
Abstract: The native South American palm açaí berry (Euterpe oleraceae Mart.) has high polyphenolic and antioxidant levels. This study examined whether açaí berry extract afforded protection against β-amyloid (Aβ)-mediated loss of cell viability and oxidative stress associated with anti-fibrillar effects. PC12 cells were exposed to either Aβ1-42, Aβ25-35 or tert butyl hydroperoxide (t-BHP), alone or in the presence of açaí extract (0.5-50μg/ml). Thioflavin T (ThT) binding assay and transmission electron microscopy were used to determine effects of açaí extract on Aβ1-42 fibril morphology and compared to açaí phenolics gallic acid, cyanidin rutinoside and cyanidin glucoside. Exposure to Aβ1-42, Aβ25-35 or t-BHP decreased PC12 cell viability. Pretreatment with açaí extract significantly improved cell viability following Aβ1-42 exposure, however Aβ25-35 or t-BHP-mediated viability loss was unaltered. Açaí extract inhibited ThT fluorescence and disrupted Aβ1-42 fibril and aggregate morphology. In comparison with other phenolics, açaí was most effective at inhibiting Aβ1-42 aggregation. Inhibition of β-amyloid aggregation may underlie a neuroprotective effect of açaí.
Keywords: Açaí
Amyloid-β
Cyanidin glucoside
Cyanidin rutinoside
Gallic acid
Oxidative stress
Rights: © 2013 Elsevier Ireland Ltd.
DOI: 10.1016/j.neulet.2013.10.027
Published version: http://dx.doi.org/10.1016/j.neulet.2013.10.027
Appears in Collections:Aurora harvest
Pharmacology publications

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