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https://hdl.handle.net/2440/81631
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dc.contributor.author | Wong, D. | - |
dc.contributor.author | Musgrave, I. | - |
dc.contributor.author | Harvey, B. | - |
dc.contributor.author | Smid, S. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Neuroscience Letters, 2013; 556:221-226 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.issn | 1872-7972 | - |
dc.identifier.uri | http://hdl.handle.net/2440/81631 | - |
dc.description.abstract | The native South American palm açaí berry (Euterpe oleraceae Mart.) has high polyphenolic and antioxidant levels. This study examined whether açaí berry extract afforded protection against β-amyloid (Aβ)-mediated loss of cell viability and oxidative stress associated with anti-fibrillar effects. PC12 cells were exposed to either Aβ1-42, Aβ25-35 or tert butyl hydroperoxide (t-BHP), alone or in the presence of açaí extract (0.5-50μg/ml). Thioflavin T (ThT) binding assay and transmission electron microscopy were used to determine effects of açaí extract on Aβ1-42 fibril morphology and compared to açaí phenolics gallic acid, cyanidin rutinoside and cyanidin glucoside. Exposure to Aβ1-42, Aβ25-35 or t-BHP decreased PC12 cell viability. Pretreatment with açaí extract significantly improved cell viability following Aβ1-42 exposure, however Aβ25-35 or t-BHP-mediated viability loss was unaltered. Açaí extract inhibited ThT fluorescence and disrupted Aβ1-42 fibril and aggregate morphology. In comparison with other phenolics, açaí was most effective at inhibiting Aβ1-42 aggregation. Inhibition of β-amyloid aggregation may underlie a neuroprotective effect of açaí. | - |
dc.description.statementofresponsibility | Daphne Yiu San Wong, Ian Francis Musgrave, Benjamin Scott Harvey, Scott Darryl Smid | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ireland Ltd | - |
dc.rights | © 2013 Elsevier Ireland Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.neulet.2013.10.027 | - |
dc.subject | Açaí | - |
dc.subject | Amyloid-β | - |
dc.subject | Cyanidin glucoside | - |
dc.subject | Cyanidin rutinoside | - |
dc.subject | Gallic acid | - |
dc.subject | Oxidative stress | - |
dc.title | Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro | - |
dc.title.alternative | Acai (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against beta-amyloid exposure in vitro | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.neulet.2013.10.027 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Musgrave, I. [0000-0003-1016-0588] | - |
dc.identifier.orcid | Smid, S. [0000-0003-4192-7219] | - |
Appears in Collections: | Aurora harvest Pharmacology publications |
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