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|Title:||Maternal thromboxane and prostacyclin levels in relation to fetal birth weight|
|Author:||de Jong, C.|
van Geijn, G.
van Kamp, G.
van Dis, H.
|Citation:||European Journal of Obstetrics Gynecology and Reproductive Biology, 2000; 93(1):65-69|
|Publisher:||Elsevier Sci Ireland Ltd|
|Catharina L.D. de Jong, Marieke Paarlberg, Herman P. van Geijn, Gerard J. van Kamp, Huib van Dis and Guus A. Dekker.|
|Abstract:||Objective: To analyse whether pregnancies resulting in a small for gestational age neonate are preceded by a prostacyclin deficiency or an imbalance between thromboxane and prostacyclin. Study design: At five fixed time points during pregnancy, 24-h urine samples were collected for the measurement of thromboxane and prostacyclin metabolites thromboxane-B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α). In order to study trend differences between pregnancies with appropriate (AGA; n=26) and small for gestational age neonates (SGA; n=17), trend analysis with simple contrasts were accomplished for TXB2, 6-keto-PGF1α and the TXB2/6-keto-PGF1α ratio. Results: Trend analysis showed higher TXB2 levels and higher TXB2/6-keto-PGF1α ratios in patients with SGA versus AGA newborns. No statistically significant difference in 6-keto-PGF1α excretion between patients with SGA and AGA newborns was detected. Conclusion: The birth of an SGA neonate is not preceded by prostacyclin deficiency. With ongoing pregnancy an imbalance between thromboxane and prostacyclin becomes more obvious in pregnancies with SGA newborns.|
|Keywords:||Humans; Pre-Eclampsia; Birth Weight; 6-Ketoprostaglandin F1 alpha; Thromboxane B2; Gestational Age; Pregnancy; Adult; Infant, Newborn; Infant, Small for Gestational Age; Female|
|Description:||Copyright © 2000 Elsevier Science Ireland Ltd. All rights reserved.|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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