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https://hdl.handle.net/2440/8166
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dc.contributor.author | de Jong, C. | - |
dc.contributor.author | Paarlberg, K. | - |
dc.contributor.author | van Geijn, G. | - |
dc.contributor.author | van Kamp, G. | - |
dc.contributor.author | van Dis, H. | - |
dc.contributor.author | Dekker, G. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | European Journal of Obstetrics Gynecology and Reproductive Biology, 2000; 93(1):65-69 | - |
dc.identifier.issn | 0301-2115 | - |
dc.identifier.issn | 1872-7654 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8166 | - |
dc.description | Copyright © 2000 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.description.abstract | Objective: To analyse whether pregnancies resulting in a small for gestational age neonate are preceded by a prostacyclin deficiency or an imbalance between thromboxane and prostacyclin. Study design: At five fixed time points during pregnancy, 24-h urine samples were collected for the measurement of thromboxane and prostacyclin metabolites thromboxane-B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α). In order to study trend differences between pregnancies with appropriate (AGA; n=26) and small for gestational age neonates (SGA; n=17), trend analysis with simple contrasts were accomplished for TXB2, 6-keto-PGF1α and the TXB2/6-keto-PGF1α ratio. Results: Trend analysis showed higher TXB2 levels and higher TXB2/6-keto-PGF1α ratios in patients with SGA versus AGA newborns. No statistically significant difference in 6-keto-PGF1α excretion between patients with SGA and AGA newborns was detected. Conclusion: The birth of an SGA neonate is not preceded by prostacyclin deficiency. With ongoing pregnancy an imbalance between thromboxane and prostacyclin becomes more obvious in pregnancies with SGA newborns. | - |
dc.description.statementofresponsibility | Catharina L.D. de Jong, Marieke Paarlberg, Herman P. van Geijn, Gerard J. van Kamp, Huib van Dis and Guus A. Dekker. | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/505961/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ireland Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/s0301-2115(00)00266-9 | - |
dc.subject | Humans | - |
dc.subject | Pre-Eclampsia | - |
dc.subject | Birth Weight | - |
dc.subject | 6-Ketoprostaglandin F1 alpha | - |
dc.subject | Thromboxane B2 | - |
dc.subject | Gestational Age | - |
dc.subject | Pregnancy | - |
dc.subject | Adult | - |
dc.subject | Infant, Newborn | - |
dc.subject | Infant, Small for Gestational Age | - |
dc.subject | Female | - |
dc.title | Maternal thromboxane and prostacyclin levels in relation to fetal birth weight | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0301-2115(00)00266-9 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Dekker, G. [0000-0002-7362-6683] | - |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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