Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/81699
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Type: Journal article
Title: Graphene and graphene oxide as new nanocarriers for drug delivery applications
Author: Liu, J.
Cui, L.
Losic, D.
Citation: Acta Biomaterialia, 2013; 9(12):9243-9257
Publisher: Elsevier BV
Issue Date: 2013
ISSN: 1742-7061
1878-7568
Statement of
Responsibility: 
Jingquan Liu, Liang Cui, Dusan Losic
Abstract: The biomedical applications of graphene-based materials, including drug delivery, have grown rapidly in the past few years. Graphene and graphene oxide have been extensively explored as some of the most promising biomaterials for biomedical applications due to their unique properties: two-dimensional planar structure, large surface area, chemical and mechanical stability, superb conductivity and good biocompatibility. These properties result in promising applications for the design of advanced drug delivery systems and delivery of a broad range of therapeutics. In this review we present an overview of recent advances in this field of research. We briefly describe current methods for the surface modification of graphene-based nanocarriers, their biocompatibility and toxicity, followed by a summary of the most appealing examples demonstrated for the delivery of anti-cancer drugs and genes. Additionally, new drug delivery concepts based on controlling mechanisms, including targeting and stimulation with pH, chemical interactions, thermal, photo- and magnetic induction, are discussed. Finally the review is summarized, with a brief conclusion of future prospects and challenges in this field.
Keywords: Graphene; Graphene oxide; Nano-carriers; Drug delivery; Targeted drug delivery
Rights: Crown Copyright © 2013
RMID: 0020133021
DOI: 10.1016/j.actbio.2013.08.016
Appears in Collections:Chemical Engineering publications

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