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https://hdl.handle.net/2440/8171
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dc.contributor.author | Yuen, B. | - |
dc.contributor.author | Owens, P. | - |
dc.contributor.author | Muhlhausler, B. | - |
dc.contributor.author | Roberts, C. | - |
dc.contributor.author | Symonds, M. | - |
dc.contributor.author | Keisler, D. | - |
dc.contributor.author | McFarlane, J. | - |
dc.contributor.author | Kauter, K. | - |
dc.contributor.author | Evens, Y. | - |
dc.contributor.author | McMillen, I. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | The FASEB Journal, 2003; 17(6):www 1-www 22 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.issn | 1530-6860 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8171 | - |
dc.description.abstract | This study aimed to determine for the first time whether leptin can act to alter the structural and functional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline was infused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation (term=147±3 days). Circulating leptin concentrations were increased approximately four- to fivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion of smaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associated with a significant increase in the proportion of multilocular tissue and a significant decrease in the proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance of leptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was a positive correlation between the relative abundance of leptin mRNA and the proportion of unilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher (P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstration that leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, and potential thermogenic functions of fat before birth. | - |
dc.description.statementofresponsibility | B. S. J. Yuen, P. C. Owens, B. S. Muhlhausler, C. T. Roberts, M. E. Symonds, D. H. Keisler, J. R. McFarlane, K. G. Kauter, Y. Evens, and I. C. McMillen | - |
dc.language.iso | en | - |
dc.publisher | Federation Amer Soc Exp Biol | - |
dc.rights | © Federation of American Societies for Experimental Biology | - |
dc.source.uri | http://dx.doi.org/10.1096/fj.02-0756fje | - |
dc.subject | fetus | - |
dc.subject | lipid | - |
dc.subject | UCP1 | - |
dc.title | Leptin alters the structural and functional characteristics of adipose tissue before birth | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1096/fj.02-0756fje | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Muhlhausler, B. [0000-0002-9021-6790] | - |
dc.identifier.orcid | Roberts, C. [0000-0002-9250-2192] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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