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https://hdl.handle.net/2440/81961
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Type: | Journal article |
Title: | The role of L-arginine in the prevention and treatment of pre-eclampsia: a systematic review of randomised trials |
Author: | Dorniak-Wall, T. Grivell, R. Dekker, G. Hague, W. Dodd, J. |
Citation: | Journal of Human Hypertension, 2014; 28(4):230-235 |
Publisher: | Nature Publishing Group |
Issue Date: | 2014 |
ISSN: | 0950-9240 1476-5527 |
Organisation: | Robinson Institute |
Statement of Responsibility: | T Dorniak-Wall, RM Grivell, GA Dekker, W Hague, and JM Dodd |
Abstract: | Pre-eclampsia is a significant health issue in pregnancy, complicating between 2-8% of pregnancies. L-arginine is an important mediator of vasodilation with a potential preventative role in pregnancy related hypertensive diseases. We aimed to systematically review randomised trials in the literature assessing the role of L-arginine in prevention and treatment of pre-eclampsia. We searched the Cochrane Controlled Trials Register, PUBMED, and the Australian and International Clinical Trials Registry, to identify randomised trials involving pregnant women where L-arginine was administered for pre-eclampsia to improve maternal and infant health outcomes. We identified eight randomised trials, seven of which were included. The methodological quality was fair, with a combined sample size of 884 women. For women at risk of pre-eclampsia, L-arginine was associated with a reduction in pre-eclampsia (RR: 0.34, 95% CI: 0.21-0.55), when compared with placebo and a reduction in risk of preterm birth (RR: 0.48 and 95% CI: 0.28 to 0.81). For women with established hypertensive disease, L-arginine was associated with a reduction in pre-eclampsia (RR: 0.21; 95% CI: 0.05-0.98). L-arginine may have a role in the prevention and/or treatment of pre-eclampsia. Further well-designed and adequately powered trials are warranted, both in women at risk of pre-eclampsia and in women with established disease. |
Keywords: | pregnancy L-arginine pre-eclampsia hypertensive disease |
Rights: | © 2013 Macmillan Publishers Limited |
DOI: | 10.1038/jhh.2013.100 |
Published version: | http://dx.doi.org/10.1038/jhh.2013.100 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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