Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/81982
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Placental restriction of fetal growth reduces cutaneous responses to antigen after sensitization in sheep
Author: Wooldridge, A.
Bischof, R.
Meeusen, E.
Liu, H.
Heinemann, G.
Hunter, D.
Giles, L.
Kind, K.
Owens, J.
Clifton, V.
Gatford, K.
Citation: American Journal of Physiology, Regulatory, Integrative and Comparative Physiology, 2014; 306(7):R441-R446
Publisher: American Physiological Society
Issue Date: 2014
ISSN: 0363-6119
1522-1490
Statement of
Responsibility: 
Amy L. Wooldridge, Robert J. Bischof, Els N. Meeusen, Hong Liu, Gary K. Heinemann, Damien S. Hunter, Lynne C. Giles, Karen L. Kind, Julie A. Owens, Vicki L. Clifton, Kathryn L. Gatford
Abstract: Prenatal and early childhood exposures are implicated as causes of allergy, but the effects of intrauterine growth restriction on immune function and allergy are poorly defined. We therefore evaluated effects of experimental restriction of fetal growth on immune function and allergic sensitization in adolescent sheep. Immune function (circulating total red and white blood cells, neutrophils, lymphocytes, monocytes, eosinophils and basophils, and the antibody response to Clostridial vaccination) and responses to house dust mite (HDM) allergen and ovalbumin (OVA) antigen sensitization (specific total Ig, IgG1 and IgE antibodies, and cutaneous hypersensitivity) were investigated in adolescent sheep from placentally-restricted (PR, n = 23) and control (n = 40) pregnancies. Increases in circulating HDM-specific IgE (P = 0.007) and OVA-specific IgE (P = 0.038) were greater in PR than control progeny. PR did not alter total Ig, IgG1 or IgM responses to either antigen. PR increased OVA-specific but not HDM-specific IgA responses in females only (P = 0.023). Multiple birth increased Ig responses to OVA in a sex-specific manner. PR decreased the proportion of positive cutaneous hypersensitivity responders to OVA at 24 h (P = 0.030), but had no effect on cutaneous responses to HDM. Acute wheal responses to intradermal histamine correlated positively with birth weight in singletons (P = 0.023). Intrauterine growth restriction may suppress inflammatory responses in skin downstream of IgE induction, without impairment in antibody responses to a non-polysaccharide vaccine. Discord between cutaneous and IgE responses following sensitization suggests new mechanisms for prenatal allergy programming.
Keywords: Animals; Sheep; Clostridium; Fetal Growth Retardation; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Disease Models, Animal; Birth Weight; Histamine; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Insect Proteins; Immunization; Bacterial Vaccines; Antibodies, Bacterial; Antigens; Skin Tests; Gestational Age; Age Factors; Pyroglyphidae; Ovalbumin; Pregnancy; Skin; Female; Male
Rights: Copyright © 2014 by the American Physiological Society.
RMID: 0030000176
DOI: 10.1152/ajpregu.00432.2013
Published version: http://ajpregu.physiology.org/content/early/2014/01/31/ajpregu.00432.2013
Appears in Collections:Paediatrics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.