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Type: Journal article
Title: Epigenetic risks related to assisted reproductive technologies - Short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?
Author: Thompson, J.
Kind, K.
Roberts, C.
Robertson, S.
Robinson, J.
Citation: Human Reproduction, 2002; 17(11):2783-2786
Publisher: Oxford Univ Press
Issue Date: 2002
ISSN: 0268-1161
Statement of
Jeremy G. Thompson, Karen L. Kind, Claire T. Roberts, Sarah A. Robertson and Jeffrey S. Robinson
Abstract: Does the manipulation of gametes and embryos as practised in human IVF invoke perturbations in fetal and neonatal phenotype? There is increasing evidence that the answer is ‘yes’, although the degree of perturbation may be less acute than observed in other species. However, the long-term consequences are not known, and may prove to be considerable. There is now a substantial body of evidence from animal models suggesting that assisted reproductive technologies (ART) are associated with altered outcomes in fetal and neonatal development. Epigenetic modification of gene expression is an attractive hypothesis that accounts for these differences and is one of a number of causal pathways that may be activated by cellular stress invoked during manipulation. Here we widen the debate to propose that environment-induced cellular stress also acts to modify fetal and placental gene expression, potentially also contributing to phenotype skewing after ART.
Keywords: Embryo culture; epigenetic; fetal development; gene expression; placenta
Description: © 2002 European Society of Human Reproduction and Embryology
RMID: 0020021220
DOI: 10.1093/humrep/17.11.2783
Appears in Collections:Obstetrics and Gynaecology publications
Agriculture, Food and Wine publications

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