Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8204
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dc.contributor.authorThompson, J.en
dc.contributor.authorKind, K.en
dc.contributor.authorRoberts, C.en
dc.contributor.authorRobertson, S.en
dc.contributor.authorRobinson, J.en
dc.date.issued2002en
dc.identifier.citationHuman Reproduction, 2002; 17(11):2783-2786en
dc.identifier.issn0268-1161en
dc.identifier.issn1460-2350en
dc.identifier.urihttp://hdl.handle.net/2440/8204-
dc.description© 2002 European Society of Human Reproduction and Embryologyen
dc.description.abstractDoes the manipulation of gametes and embryos as practised in human IVF invoke perturbations in fetal and neonatal phenotype? There is increasing evidence that the answer is ‘yes’, although the degree of perturbation may be less acute than observed in other species. However, the long-term consequences are not known, and may prove to be considerable. There is now a substantial body of evidence from animal models suggesting that assisted reproductive technologies (ART) are associated with altered outcomes in fetal and neonatal development. Epigenetic modification of gene expression is an attractive hypothesis that accounts for these differences and is one of a number of causal pathways that may be activated by cellular stress invoked during manipulation. Here we widen the debate to propose that environment-induced cellular stress also acts to modify fetal and placental gene expression, potentially also contributing to phenotype skewing after ART.en
dc.description.statementofresponsibilityJeremy G. Thompson, Karen L. Kind, Claire T. Roberts, Sarah A. Robertson and Jeffrey S. Robinsonen
dc.language.isoenen
dc.publisherOxford Univ Pressen
dc.subjectEmbryo culture; epigenetic; fetal development; gene expression; placentaen
dc.titleEpigenetic risks related to assisted reproductive technologies - Short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?en
dc.typeJournal articleen
dc.identifier.rmid0020021220en
dc.identifier.doi10.1093/humrep/17.11.2783en
dc.identifier.pubid59911-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidThompson, J. [0000-0003-4941-7731]en
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]en
dc.identifier.orcidRobertson, S. [0000-0002-9967-0084]en
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]en
Appears in Collections:Obstetrics and Gynaecology publications
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