Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorThompson, J.en
dc.contributor.authorKind, K.en
dc.contributor.authorRoberts, C.en
dc.contributor.authorRobertson, S.en
dc.contributor.authorRobinson, J.en
dc.identifier.citationHuman Reproduction, 2002; 17(11):2783-2786en
dc.description© 2002 European Society of Human Reproduction and Embryologyen
dc.description.abstractDoes the manipulation of gametes and embryos as practised in human IVF invoke perturbations in fetal and neonatal phenotype? There is increasing evidence that the answer is ‘yes’, although the degree of perturbation may be less acute than observed in other species. However, the long-term consequences are not known, and may prove to be considerable. There is now a substantial body of evidence from animal models suggesting that assisted reproductive technologies (ART) are associated with altered outcomes in fetal and neonatal development. Epigenetic modification of gene expression is an attractive hypothesis that accounts for these differences and is one of a number of causal pathways that may be activated by cellular stress invoked during manipulation. Here we widen the debate to propose that environment-induced cellular stress also acts to modify fetal and placental gene expression, potentially also contributing to phenotype skewing after ART.en
dc.description.statementofresponsibilityJeremy G. Thompson, Karen L. Kind, Claire T. Roberts, Sarah A. Robertson and Jeffrey S. Robinsonen
dc.publisherOxford Univ Pressen
dc.subjectEmbryo culture; epigenetic; fetal development; gene expression; placentaen
dc.titleEpigenetic risks related to assisted reproductive technologies - Short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?en
dc.typeJournal articleen
pubs.library.collectionObstetrics and Gynaecology publicationsen
dc.identifier.orcidThompson, J. [0000-0003-4941-7731]en
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]en
dc.identifier.orcidRobertson, S. [0000-0002-9967-0084]en
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]en
Appears in Collections:Obstetrics and Gynaecology publications
Agriculture, Food and Wine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.