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Type: Journal article
Title: Pattern of cerebrospinal immediate early gene c-fos expression in an ovine model of non-accidental head injury
Author: Finnie, J.
Blumbergs, P.
Manavis, J.
Vink, R.
Citation: Journal of Clinical Neuroscience, 2013; 20(12):1759-1761
Publisher: Churchill Livingstone
Issue Date: 2013
ISSN: 0967-5868
Statement of
J.W. Finnie, P.C. Blumbergs, J. Manavis, R. Vink
Abstract: Expression of the immediate early gene, c-fos, was examined in a large animal model of non-accidental head injury ("shaken baby syndrome"). Lambs were used because they have a relatively large gyrencephalic brain and weak neck muscles resembling a human infant. Neonatal lambs were manually shaken in a manner similar to that believed to occur with most abused human infants, but there was no head impact. The most striking c-fos expression was in meningothelial cells of the cranial cervical spinal cord and, to a lesser degree, in hemispheric, cerebellar, and brainstem meninges. Vascular endothelial cells also frequently showed c-fos immunopositivity in the meninges and hemispheric white matter. It was hypothesised that this c-fos immunoreactivity was due to mechanical stress induced by shaking, with differential movement of different craniospinal components.
Keywords: Animal model; c-fos expression; Non-accidental head injury
Rights: Crown copyright © 2013
RMID: 0020134362
DOI: 10.1016/j.jocn.2013.03.010
Appears in Collections:Medical Sciences publications

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