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Type: Journal article
Title: TLR4/PKC-mediated tight junction modulation: a clinical marker of chemotherapy-induced gut toxicity?
Author: Wardill, H.
Gibson, R.
Logan, R.
Bowen, J.
Citation: International Journal of Cancer, 2014; 135(11):2483-2492
Publisher: John Wiley & Sons
Issue Date: 2014
ISSN: 1097-0215
Statement of
Hannah R. Wardill, Rachel J. Gibson, Richard M. Logan and Joanne M. Bowen
Abstract: Chemotherapy-induced gut toxicity is a major clinical and economic burden to oncology practice. The mechanisms responsible for its development are ill defined, hampering the development of therapeutic interventions. In light of newly published research foci and clinical practice guidelines in supportive care in cancer, there has been renewed interest in the role tight junctions play in the pathobiology of chemotherapy-induced gut toxicity. Several preclinical studies have identified molecular defects in intestinal tight junctions following chemotherapy. Despite these findings, the mechanisms responsible for chemotherapy-induced tight junction disruption remain unclear. Recent research has highlighted roles for toll-like receptor 4 and protein kinase C signalling in the regulation of tight junctions. This critical review therefore aims to provide evidence linking toll-like receptor 4 expression, protein kinase C activation and tight junction disruption and their relationship to clinical toxicity.
Keywords: mucositis; chemotherapy; tight junctions; toll-like receptor 4; protein kinase C
Rights: © 2013 UICC
RMID: 0020135427
DOI: 10.1002/ijc.28656
Appears in Collections:Anatomical Sciences publications

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