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https://hdl.handle.net/2440/82658
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Type: | Journal article |
Title: | Gut motility and enteroendocrine secretion |
Author: | Wu, T. Rayner, C. Young, R. Horowitz, M. |
Citation: | Current Opinion in Pharmacology, 2013; 13(6):928-934 |
Publisher: | Elsevier Science Ltd |
Issue Date: | 2013 |
ISSN: | 1471-4892 1471-4973 |
Statement of Responsibility: | Tongzhi Wu, Christopher K Rayner, Richard L Young, Michael Horowitz |
Abstract: | The motility of the gastrointestinal (GI) tract is modulated by complex neural and hormonal networks; the latter include gut peptides released from enteroendocrine cells during both the interdigestive and postprandial periods. Conversely, it is increasingly recognised that GI motility is an important determinant of gut hormone secretion, in that the transit of luminal contents influences the degree of nutrient stimulation of enteroendocrine cells in different gut regions, as well as the overall length of gut exposed to nutrient. Of particular interest is the relationship between gallbladder emptying and enteroendocrine secretion. The inter-relationships between GI motility and enteroendocrine secretion are central to blood glucose homeostasis, where an understanding is fundamental to the development of novel strategies for the management of diabetes mellitus. |
Keywords: | Gastrointestinal Tract Animals Humans Gastrointestinal Hormones Gastrointestinal Motility Enteroendocrine Cells |
Rights: | © 2013 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.coph.2013.09.002 |
Published version: | http://dx.doi.org/10.1016/j.coph.2013.09.002 |
Appears in Collections: | Aurora harvest Medicine publications |
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