Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8267
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Type: Journal article
Title: Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition
Author: Moran, L.
Noakes, M.
Clifton, P.
Wittert, G.
Tomlinson, L.
Galletly, C.
Luscombe-Marsh, N.
Norman, R.
Citation: Journal of Clinical Endocrinology and Metabolism, 2004; 89(7):3337-3344
Publisher: Endocrine Society
Issue Date: 2004
ISSN: 0021-972X
1945-7197
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Responsibility: 
L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, L. Tomlinson, C. Galletly, N. D. Luscombe and R. J. Norman
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age associated with obesity. It may involve dysregulation of ghrelin, a hormone implicated in appetite regulation. The effect of diet composition on ghrelin is unclear. Overweight women with and without PCOS were randomized to a high-protein (40% carbohydrate, 30% protein; 10 PCOS, six non-PCOS) or standard protein diet (55% carbohydrate, 15% protein; 10 PCOS, six non-PCOS) for 12 wk of energy restriction and 4 wk of weight maintenance. Diet composition had no effect on fasting or postprandial ghrelin or measures of satiety. Non-PCOS subjects had a 70% higher fasting baseline ghrelin (P = 0.011), greater increase in fasting ghrelin (57.5 vs. 34.0%, P = 0.033), and greater maximal decrease in postprandial ghrelin after weight loss (–144.1 ± 58.4 vs. –28.9 ± 14.2 pg/ml, P = 0.02) than subjects with PCOS. Subjects with PCOS were less satiated (P = 0.001) and more hungry (P = 0.007) after a test meal at wk 0 and 16 than subjects without PCOS. Appetite regulation, as measured by subjective short-term hunger and satiety and ghrelin homeostasis, may be impaired in PCOS.
Keywords: Humans; Polycystic Ovary Syndrome; Obesity; Body Weight; Insulin; Peptide Hormones; Blood Glucose; Dietary Proteins; Pain Measurement; Caloric Restriction; Diet; Fasting; Regression Analysis; Patient Compliance; Satiety Response; Body Composition; Homeostasis; Postprandial Period; Adult; Middle Aged; Female; Ghrelin
Description: Copyright © 2004 by The Endocrine Society
RMID: 0020040576
DOI: 10.1210/jc.2003-031583
Published version: http://jcem.endojournals.org/cgi/content/abstract/89/7/3337
Appears in Collections:Psychiatry publications
Obstetrics and Gynaecology publications
Medicine publications

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