Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition|
|Citation:||Journal of Clinical Endocrinology and Metabolism, 2004; 89(7):3337-3344|
|L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, L. Tomlinson, C. Galletly, N. D. Luscombe and R. J. Norman|
|Abstract:||Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age associated with obesity. It may involve dysregulation of ghrelin, a hormone implicated in appetite regulation. The effect of diet composition on ghrelin is unclear. Overweight women with and without PCOS were randomized to a high-protein (40% carbohydrate, 30% protein; 10 PCOS, six non-PCOS) or standard protein diet (55% carbohydrate, 15% protein; 10 PCOS, six non-PCOS) for 12 wk of energy restriction and 4 wk of weight maintenance. Diet composition had no effect on fasting or postprandial ghrelin or measures of satiety. Non-PCOS subjects had a 70% higher fasting baseline ghrelin (P = 0.011), greater increase in fasting ghrelin (57.5 vs. 34.0%, P = 0.033), and greater maximal decrease in postprandial ghrelin after weight loss (–144.1 ± 58.4 vs. –28.9 ± 14.2 pg/ml, P = 0.02) than subjects with PCOS. Subjects with PCOS were less satiated (P = 0.001) and more hungry (P = 0.007) after a test meal at wk 0 and 16 than subjects without PCOS. Appetite regulation, as measured by subjective short-term hunger and satiety and ghrelin homeostasis, may be impaired in PCOS.|
|Keywords:||Humans; Polycystic Ovary Syndrome; Obesity; Body Weight; Insulin; Peptide Hormones; Blood Glucose; Dietary Proteins; Pain Measurement; Caloric Restriction; Diet; Fasting; Regression Analysis; Patient Compliance; Satiety Response; Body Composition; Homeostasis; Postprandial Period; Adult; Middle Aged; Female; Ghrelin|
|Description:||Copyright © 2004 by The Endocrine Society|
|Appears in Collections:||Psychiatry publications|
Obstetrics and Gynaecology publications
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.