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https://hdl.handle.net/2440/8277
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Type: | Journal article |
Title: | Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig |
Author: | Conlon, M. Tomas, F. Owens, P. Wallace, J. Howarth, G. Ballard, F. |
Citation: | Journal of Endocrinology, 1995; 146(2):247-253 |
Publisher: | The Society for Endocrinology |
Issue Date: | 1995 |
ISSN: | 0022-0795 1479-6805 |
Abstract: | We have tested whether an animal with substantial amounts of both IGF-I and IGF-II in circulation, such as the guinea pig, would respond to chronic IGF infusion in the same manner as the adult rat, which has negligible amounts of IGF-II in blood. Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins. IGF-I or IGF-II infusion led to substantial increases in plasma IGF-I or IGF-II respectively in comparison with vehicle-infused animals. Nevertheless, body weight gain, feed intake, feed conversion efficiency and carcass composition were not significantly affected by any treatment (significance was deemed to be P < 0.05). Amongst the tissues examined only the fractional weight (g/kg body weight) of the adrenals was increased, and that only by the higher dose (360 micrograms/day) of IGF-I. However, the fractional weight of adrenals, gut, kidneys and spleen were significantly increased by LR3IGF-I, but again overall growth was not stimulated. A possible explanation for the lack of IGF-I effects is that total circulating IGF concentrations were not increased by these treatments. IGF-II significantly raised total IGF concentrations at the higher dose only. Plasma IGF-I was reduced by IGF-II infusion, as was plasma IGF-II by IGF-I infusion.(ABSTRACT TRUNCATED AT 250 WORDS) |
Keywords: | Intestines Kidney Adrenal Glands Spleen Animals Guinea Pigs Somatomedins Insulin-Like Growth Factor I Insulin-Like Growth Factor II Insulin-Like Growth Factor Binding Protein 1 Organ Size Female |
DOI: | 10.1677/joe.0.1460247 |
Published version: | http://dx.doi.org/10.1677/joe.0.1460247 |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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