Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/83074
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMulholland, C.-
dc.contributor.authorSomogyi, A.-
dc.contributor.authorBarratt, D.-
dc.contributor.authorColler, J.-
dc.contributor.authorHutchinson, M.-
dc.contributor.authorJacobson, G.-
dc.contributor.authorCursons, R.-
dc.contributor.authorSleigh, J.-
dc.date.issued2014-
dc.identifier.citationJournal of Molecular Neuroscience, 2014; 52(4):497-506-
dc.identifier.issn0895-8696-
dc.identifier.issn1559-1166-
dc.identifier.urihttp://hdl.handle.net/2440/83074-
dc.descriptionPublished online: 19 December 2013-
dc.description.abstractThe electroencephalogram (EEG) records the electrical activity of the brain and enables effects of anaesthetic drugs on brain functioning to be monitored. Identification of genes contributing to EEG variability during anaesthesia is important to the clinical application of anaesthesia monitoring and may provide an avenue to identify molecular mechanisms underlying the generation and regulation of brain oscillations. Central immune signalling can impact neuronal activity in the brain and accumulating evidence suggests an important role for cytokines as neuronal modulators. We tested 21 single-nucleotide polymorphisms (SNPs) in immune-related genes for associations with three anaesthesia-induced EEG patterns; spindle amplitude, delta power and alpha power, during general anaesthesia with desflurane in 111 patients undergoing general, gynaecological or orthopaedic surgery. Wide inter-patient variability was observed for all EEG variables. MYD88 rs6853 (p = 6.7 × 10−4) and IL-1β rs1143627 in conjunction with rs6853 (p = 1.5 × 10−3) were associated with spindle amplitude, and IL-10 rs1800896 was associated with delta power (p = 1.3 × 10−2) suggesting involvement of cytokine signalling in modulation of EEG patterns during desflurane anaesthesia. BDNF rs6265 was associated with alpha power (p = 3.9 × 10−3), suggesting differences in neuronal plasticity might also influence EEG patterns during desflurane anaesthesia. This is the first study we are aware of that has investigated genetic polymorphisms that may influence the EEG during general anaesthesia.-
dc.description.statementofresponsibilityClaire Vignette Mulholland, Andrew Alexander Somogyi, Daniel Thomas Barratt, Janet Kristie Coller, Mark Rowland Hutchinson, Gregory Michael Jacobson, Raymond Thomas Cursons and James Wallace Sleigh-
dc.language.isoen-
dc.publisherHumana Press Inc-
dc.rights© Springer Science+Business Media New York 2013-
dc.source.urihttp://dx.doi.org/10.1007/s12031-013-0201-7-
dc.subjectElectroencephalogram-
dc.subjectAnaesthesia-
dc.subjectSNP-
dc.subjectCytokine-
dc.subjectInflammation-
dc.subjectIL-1β-
dc.titleAssociation of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia-
dc.typeJournal article-
dc.identifier.doi10.1007/s12031-013-0201-7-
pubs.publication-statusPublished-
dc.identifier.orcidSomogyi, A. [0000-0003-4779-0380]-
dc.identifier.orcidBarratt, D. [0000-0001-6261-353X]-
dc.identifier.orcidColler, J. [0000-0002-8273-5048]-
dc.identifier.orcidHutchinson, M. [0000-0003-2154-5950]-
Appears in Collections:Aurora harvest
Pharmacology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.