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https://hdl.handle.net/2440/8344
Type: | Journal article |
Title: | hRLX-1 in vitro response of human and pig myometrium |
Author: | MacLennan, A. Grant, P. Bryant-Greenwood, G. |
Citation: | Journal of Reproductive Medicine: for the obstetrician and gynecologist, 1995; 40(10):703-706 |
Publisher: | Journal of Reproductive Medicine Inc. |
Issue Date: | 1995 |
ISSN: | 0024-7758 1943-3565 |
Abstract: | <h4>Objective</h4>To study the effect of synthetic h RLX-1 peptide on human and porcine myometrium in vitro in comparison to the effect of h RLX-2 peptide.<h4>Study design</h4>Myometrial strips from humans and pigs in late pregnancy were allowed to spontaneously contract in an organ bath. Muscle activity was recorded isometrically in response to varying doses of h RLX-1.<h4>Results</h4>Synthetic h RLX-1 peptide at 0.13 micrograms/mL caused sustained and complete inhibition of pregnant pig myometrial contractility, comparable to that produced by the h RLX-2 peptide, showing, for the first time, its biologic activity in this system. However, a range of concentrations of h RLX-1 peptide (0.07-7.32 micrograms/mL) had no effect on human myometrial contractions in vitro, whereas h RLX-2 peptide had some, albeit minimal, activity in this system.<h4>Conclusion</h4>This result shows that h RLX-1 peptide does not appear to be an inhibitor of human myometrial activity and that although the pig myometrial relaxin receptor does not appear to distinguish between the two human relaxins, the human relaxin receptor might. Thus, the control of spontaneous myometrial activity during pregnancy in the human appears to be different from that in other species. |
Keywords: | Myometrium Animals Swine Humans Relaxin Recombinant Proteins Drug Evaluation, Preclinical Pregnancy Uterine Contraction Dose-Response Relationship, Drug Female In Vitro Techniques |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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